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Sales and immunogenicity of commercial vaccines to H9N2 low pathogenic avian influenza virus in Korea from 2007 to 2017

机译:2007年至2017年韩国商业疫苗对H9N2低病原禽流感病毒的销售和免疫原性

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The present study was conducted to monitor sales activity and immunogenicity of commercial H9N2 vaccines produced in Korea from 2007 to 2017. Recorded sales of H9N2 vaccine were around 671 million doses, with 10 million doses sold in 2007, rising to a peak of 93 million doses in 2016, with a slight fall in 2017. Multivalent combined vaccines made up around 90% of all vaccine sales, and around 30% of all vaccines were distributed by regional governments for free. The regional vaccination rate was the highest in Gyeonggi and Chungnam, respectively with proportional to the population of layer and breeder chickens. There have been no cases of field infection since 2009. The mean antibody titer was 5.82 log2 across the study period. Our results suggest that continuous genetic monitoring of H9N2 viruses circulating in the field and updating the vaccine seed strain periodically are necessary in order to control H9N2 outbreaks. (C) 2020 Elsevier Ltd. All rights reserved.
机译:目前的研究是为了监测2007年至2017年韩国商业H9N2疫苗的销售活性和免疫原性。H9N2疫苗的记录销售额约为6.71亿剂,2007年销售1000万剂,升至9300万剂量的峰值 2016年,2017年略有下跌。多价组合疫苗占所有疫苗销售额约为90%,占所有疫苗的约30%是由地区政府免费分发的。 区域疫苗接种率是京畿道和朝鲜的最高,分别与层和饲养鸡群成正比。 自2009年以来一直没有野外感染。平均抗体滴度在研究期间为5.82 log2。 我们的研究结果表明,在现场循环的H9N2病毒的连续遗传监测以及定期更新疫苗种子株,以控制H9N2爆发。 (c)2020 elestvier有限公司保留所有权利。

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