Improvement of a recombinant avian avulavirus serotype 10 vectored vaccine by the addition of untranslated regions

Tsunekuni Ryota; Tanikawa Taichiro; Nakaya Takaaki; Saito Takehiko

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Improvement of a recombinant avian avulavirus serotype 10 vectored vaccine by the addition of untranslated regions

机译：通过添加未翻译的区域改善重组禽Avulavirus血清型10的疫苗

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Background: We have previously developed a recombinant avian avulavirus serotype 10 (rAAvV-10/HA) expressing the hemagglutinin (HA) gene of a highly pathogenic avian influenza virus (HPAIV) as an emergency vaccine for poultry. rAAvV-10/HA can overcome the activity of the anti-AAvV-1 (Newcastle disease virus) antibody acquired by commercial chickens upon routine vaccination. Most chickens do not have the anti-AAvV-10 antibody, which could interfere with the vaccine efficacy. However, the vaccine efficacy of rAAvV-10/HA is not satisfactory in chickens even though it affords protection against an HPAIV challenge. In the present study, we improved the rAAvV-10/HA vaccine by enhancing the expression of the exogenous HA protein.

机译：背景：我们以前开发了一种重组禽Avulavirus血清型10（RAAVV-10 / HA），其表达高致病性禽流感病毒（HPAIV）的血凝素（HA）基因作为家禽的应急疫苗。 raavv-10 / ha可以在常规疫苗接种时克服由商业鸡获得的抗AAVV-1（新城疫病毒）抗体的活性。大多数鸡没有抗AAVV-10抗体，这可能会干扰疫苗疗效。然而，即使它为HPAIV挑战提供保护，RAAVV-10 / HA的疫苗疗效也不会令人满意的鸡。在本研究中，通过增强外源HA蛋白的表达，我们改善了RAAVV-10 / HA疫苗。

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来源
《Vaccine》 |2020年第4期|共8页
作者
Tsunekuni Ryota; Tanikawa Taichiro; Nakaya Takaaki; Saito Takehiko;
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作者单位

Natl Agr &

Food Res Org Div Transboundary Anim Dis Natl Inst Anim Hlth 3-1-5 Kannondai Tsukuba Ibaraki 3050854 Japan;

Natl Agr &

Food Res Org Div Transboundary Anim Dis Natl Inst Anim Hlth 3-1-5 Kannondai Tsukuba Ibaraki 3050854 Japan;

Kyoto Prefectural Univ Med Grad Sch Med Sci Dept Infect Dis Kamigyo Ku Kajii Cho Kawaramachi Hirokoji Kyoto 6028566 Japan;

Natl Agr &

Food Res Org Div Transboundary Anim Dis Natl Inst Anim Hlth 3-1-5 Kannondai Tsukuba Ibaraki 3050854 Japan;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Avian avulavirus (AAvV); Highly pathogenic avian influenza (HPAI); Vaccine vector; Emergency vaccination; Untranslated region (UTR);

机译：Avian Avulavirus（AAVV）;高致病性禽流感（HPAI）;疫苗载体;应急疫苗接种;未转换地区（UTR）;

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专利

1. Improvement of a recombinant avian avulavirus serotype 10 vectored vaccine by the addition of untranslated regions [J] . Tsunekuni Ryota, Tanikawa Taichiro, Nakaya Takaaki, Vaccine . 2020,第4期

机译：通过添加未翻译的区域改善重组禽Avulavirus血清型10的疫苗
2. Recombinant Avian Paramyxovirus Serotypes 2, 6, and 10 as Vaccine Vectors for Highly Pathogenic Avian Influenza in Chickens with Antibodies Against Newcastle Disease Virus [J] . Avian Diseases . 2017,第3期

机译：重组禽副磷术病毒2,6和10作为疫苗载体，用于鸡中的高致病性禽流感，患有针对新城疫病毒的抗体
3. Evaluation of avian paramyxovirus serotypes 2 to 10 as vaccine vectors in chickens previously immunized against Newcastle disease virus [J] . Tsunekuni R, Hikono H, Saito T Veterinary Immunology and Immunopathology . 2014,第3a4期

机译：预先免疫新城疫病毒的鸡中禽副粘病毒血清型2至10作为疫苗载体的评估
4. Development of a Recombinant Fowlpox Virus Vector-Based Vaccine of H5N1 Subtype Avian Influenza [C] . C Qiao, K. Yu, Y Jiang, International Epizootic Office/Food and Agriculture Organization fo the United Nations International Scientific Conference on Avian Influenza . 2006

机译：研发H5N1亚型禽流感的重组禽病毒载体的疫苗
5. Herpes virus of turkey-based recombinant nucleoprotein vaccine against avian influenza. [D] . Munir, Shirin. 2000

机译：土耳其针对禽流感的重组核蛋白疫苗的疱疹病毒。
6. Epitope Peptide-Based Predication and Other Functional Regions of Antigenic F and HN Proteins of Waterfowl and Poultry Avian Avulavirus Serotype-1 Isolates From Uganda [O] . John Bosco Omony, Agnes Wanyana, Kizito K. Mugimba, 2021

机译：基于表位肽的抗原F和HN蛋白的抗原F和HN蛋白的其他功能区来自乌干达的禽Avulavirus血清型-1分离物
7. Safety and Immunogenicity of a Recombinant Adenovirus Serotype 35-Vectored HIV-1 Vaccine in Adenovirus Serotype 5 Seronegative and Seropositive Individuals. [O] . Fuchs, J.D., Bart, P.A., Frahm, N., 2015

机译：在腺病毒血清型5血清反应阴性和血清反应阳性个体中，重组腺病毒血清型35-载体HIV-1疫苗的安全性和免疫原性。

Improvement of a recombinant avian avulavirus serotype 10 vectored vaccine by the addition of untranslated regions

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