...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Synergistic effect of anti-Helicobacter pylori urease immunoglobulin Y from egg yolk of immunized hens and Lactobacillus johnsonii No.1088 to inhibit the growth of Helicobacter pylon in vitro and in vivo
【24h】

Synergistic effect of anti-Helicobacter pylori urease immunoglobulin Y from egg yolk of immunized hens and Lactobacillus johnsonii No.1088 to inhibit the growth of Helicobacter pylon in vitro and in vivo

机译：免疫母鸡蛋黄和乳杆菌No.1088中蛋黄的抗幽门螺杆菌脲酶免疫球蛋白Y的协同作用，抑制体外和体内幽门螺杆菌的生长

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Helicobacter pylori is a pathogenic bacterium that infects the stomach, causing chronic gastritis; and it is also considered to be related to the occurrence of gastric cancers. Although some eradication regimens including multiple antibiotics have been developed, the emergence of resistance to antibiotics becomes problematic. Therefore, other approaches to compensate or augment the effects of standard regimens are needed. In this study, we examined the possible synergistic effects of anti-H. pylori urease IgY and Lactobacillus johnsonii No.1088 (LJ88) both in vitro and in vivo. Anti-H. pylori urease IgY was purified from egg yolks laid by the hens immunized with urease purified from H. pylori. LJ88 is a unique strain of lactic acid bacterium isolated from human gastric juice, and it has been reported to inhibit H. pylori both in vitro and in vivo. The in vitro mixed culture study showed that anti-H. pylori urease IgY augmented the anti-H. pylori activity of LJ88 against both clarithromycin-sensitive and-resistant H. pylori strains. In a germ-free mice infection model, combined administration of daily anti-H. pylori urease IgY and weekly living LJ88 significantly reduced H. pylori infections, whereas either monotherapy did not. In an in vivo human gut microbiota-associated mice model, not only daily administration of living LJ88 but also heat-killed one significantly reduced an H. pylori infection in the stomach when combined with anti-H. pylori urease IgY. The extent of reduction of the stomach H. pylori by such a combination therapy was larger than that reported for LJ88 monotherapy. These results taken together revealed a synergistic effect of anti-H. pylori urease IgY and living or heat-killed LJ88, thus suggesting that such a combination might be a promising therapy to possibly compensate and/or augment standard anti-H. pylori regimens. (C) 2019 Elsevier Ltd. All rights reserved.
机译：幽门螺杆菌是一种感染胃的病原细菌，导致慢性胃炎;它也被认为与胃癌发生有关。虽然已经开发出一些包括多种抗生素的根除方案，但对抗生素的抗性产生问题。因此，需要补偿或增强标准方案效果的其他方法。在这项研究中，我们检查了抗H的可能协同效应。幽门螺杆菌尿素Igy和乳杆菌johnsonii在体外和体内含有14088号（LJ88）。抗H。通过用从H. Pylori纯化的脲酶免疫的母猪铺设蛋黄纯化幽门螺杆菌脲酶IgY。 LJ88是从人胃液中分离的独特的乳酸菌菌株，据报道，在体外和体内抑制H.幽门螺杆菌。体外混合培养研究表明抗H。幽门尿素Igy增强抗H. LJ88对克拉霉素敏感性耐药H.幽门螺杆菌菌株的幽门螺杆菌活性。在无菌小鼠感染模型中，综合施用每日抗H.幽门螺杆菌尿素Igy和每周生活LJ88显着降低了幽门螺杆菌感染，而单方米疗法则没有。在体内人体肠道微生物群相关的小鼠模型中，不仅日常生活LJ88，而且在与抗H合并时，也显着减少了胃中的幽门螺杆菌感染。幽门螺杆菌尿素Igy。通过这种联合疗法减少胃H.幽门螺杆菌的程度大于LJ88单药治疗的寄生。这些结果结合在一起揭示了抗H的协同作用。幽门螺杆菌尿素Igy和生物或热杀死的LJ88，因此表明这种组合可能是可能补偿和/或增强标准抗H的有希望的疗法。幽门植物方案。 （c）2019 Elsevier Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号