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首页> 外文期刊>Vaccine >Raw starch microparticles as BCG adjuvant: Their efficacy depends on the virulence of the infection strains
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Raw starch microparticles as BCG adjuvant: Their efficacy depends on the virulence of the infection strains

机译：原料淀粉微粒作为BCG佐剂：它们的功效取决于感染菌株的毒力

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The persistence of tuberculosis (TB) as one of the top 10 causes of death worldwide, the growing incidence of multidrug-resistant tuberculosis and the controversial efficacy of the Bacille Calmette-Guerin (BCG) vaccine drives the development of new generation multistage vaccines against this disease that can boost BCG-primed immunity. The use of polymeric microparticles for this purpose increases due to their advantages, especially their good safety levels and intrinsic immunostimulant properties. We recently explored and demonstrated the reinforcing and adjuvant potential of starch microparticles (SMPs) that administered intranasally to BCG-primed BALB/c mice, alone or in combination with a recombinant antigen, increased survival rates and induced a reduction of bacterial load in the lungs of mice infected with tuberculosis. Here, we tested the effect of SMPs added to the BCG vaccine as adjuvant to the wholecell vaccine and investigated their contribution to the improvement of the protective efficacy of subcutaneous vaccination in mice challenged with virulent strains of Mycobacterium tuberculosis. As expected, our results were dependent on the infection strains, showing that virulence is a crucial factor that affects the adjuvant activity of SMPs. Our results also confirm the adjuvant activity of this carbohydrate and its usefulness in diverse vaccination strategies not only for mucosal but also for parenteral administration. (C) 2019 Elsevier Ltd. All rights reserved.
机译：结核病（TB）的持续存在（TB）作为全世界的十大原因之一，多药抗性结核病发病率越来越多，Bacille Calmette-guerin（BCG）疫苗的争议效果驱使新一代多级疫苗的开发疾病可以提高BCG引发的免疫力。由于其优点，使用聚合物微粒的使用增加，尤其是它们的良好安全水平和内在免疫刺激性。我们最近探讨并证明了淀粉微粒（SMP）的增强和佐剂电位，其单独或与重组抗原的单独或与重组抗原组合给药，增加存活率并诱导肺部细菌载荷的减少患有结核病感染的小鼠。在这里，我们测试了SMPs加入BCG疫苗的影响，作为辅助的疫苗，并研究了对致策致致密的分枝杆菌毒菌菌攻击的皮下疫苗接种的改善效果的贡献。正如预期的那样，我们的结果依赖于感染菌株，表明毒力是影响SMPS佐剂活性的关键因素。我们的结果还证实了这种碳水化合物的佐剂活性及其在各种疫苗接种策略中的用途，不仅适用于粘膜，还适用于肠胃外给药。 （c）2019 Elsevier Ltd.保留所有权利。

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