Is the test for irreversibility of tetanus toxoids still relevant?

Behrensdorf-Nicol Heike A.; Kraemer Beate

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Is the test for irreversibility of tetanus toxoids still relevant?

机译：Tetanus毒素不可逆转的测试仍然相关吗？

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Tetanus vaccines for human and veterinary use are based on toxoids resulting from a formaldehyde mediated inactivation of tetanus neurotoxin (TeNT). Due to the high toxicity of TeNT, safety tests are mandatory for each batch of these toxoids. One of the tests addresses the irreversibility of inactivation: The toxoid is stored at 37 degrees C for 6 weeks and then subjected to in vivo toxicity testing.

机译：用于人和兽医用途的破伤风疫苗基于甲醛介导的破伤风神经毒素（帐篷）的甲醛灭活而产生的类毒素。由于帐篷的毒性高，对于每批这些毒素都是强制性的安全测试。其中一个测试解决了灭活的不可逆转性：毒素在37摄氏度储存6周，然后进行体内毒性测试。

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来源
《Vaccine》 |2019年第13期|共4页
作者
Behrensdorf-Nicol Heike A.; Kraemer Beate;
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作者单位

Paul Ehrlich Inst Fed Inst Vaccines &

Biomed Div Vet Med Paul Ehrlich Str 51-59 D-63225 Langen Germany;

Paul Ehrlich Inst Fed Inst Vaccines &

Biomed Div Vet Med Paul Ehrlich Str 51-59 D-63225 Langen Germany;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Tetanus vaccines; Toxoids; Test for irreversibility of toxoid; European Pharmacopoeia;

机译：Tetanus疫苗;毒素;毒素不可逆转的测试;欧洲药典;

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1. Is the test for irreversibility of tetanus toxoids still relevant? [J] . Behrensdorf-Nicol Heike A., Kraemer Beate Vaccine . 2019,第13期

机译：Tetanus毒素不可逆转的测试仍然相关吗？
2. Efficacy and safety of a booster dose of the meningococcal A, C, W, Y-tetanus toxoid conjugate vaccine administered 10 years after primary vaccination and long-term persistence of tetanus toxoid conjugate or polysaccharide vaccine [J] . Human vaccines & immunotherapeutics. . 2020,第6期

机译：脑膜炎球菌A，C，W，Y-Tetanus毒素结合疫苗的疗效和安全性的疗效和安全性10年施用初级疫苗接种和Tetanus毒素缀合物或多糖疫苗的长期持续性
3. Four and one-half-year follow-up of the effectiveness of diphtheria-tetanus toxoids-acellular pertussis/Haemophilus influenzae type b and diphtheria-tetanus toxoids-acellular pertussis-inactivated poliovirus/H. influenzae type b combination vaccines [J] . Kalies H, Verstraeten T, Grote V, The Pediatric infectious disease journal . 2004,第10期

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4. Synthesis of Tetanus Toxoid-Sepharose CL 4B derivatives by Rational Design [C] . B. Cutiño-Avila, E. Cunill-Semanat, D.F. Gil, Latin American congress on biomedical engineering . 2013

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5. The roles of costimulatory molecules in the cooperative effects of combination epinephrine and dexamethasone on type-1/type-2 cytokine production in tetanus-toxoid specific stimulated human peripheral blood mononuclear cells [D] . Salicru, Adriano N. 2007

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6. Can Haemophilus influenzae type b-tetanus toxoid conjugate vaccine be combined with diphtheria toxoid-pertussis vaccine-tetanus toxoid? [O] . D Scheifele, L Barreto, W Meekison, 1993

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7. Efficacy and safety of a booster dose of the meningococcal A, C, W, Y-tetanus toxoid conjugate vaccine administered 10 years after primary vaccination and long-term persistence of tetanus toxoid conjugate or polysaccharide vaccine [O] . Beatriz Quiambao, Paula Peyrani, Ping Li, 2020

机译：脑膜炎球菌A，C，W，Y-Tetanus毒素缀合物疫苗在一次疫苗接种后10年施用的疗效和安全性，染发剂毒素或多糖疫苗的长期持续存在
8. Preventing Tetanus, Diphtheria, and Pertussis Among Adults: Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine: Recommendation of ACIP, Supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC), [R] . Kretsinger, K. 2006

机译：在成人中预防破伤风，白喉和百日咳：使用破伤风类毒素，减少白喉类毒素和无细胞百日咳疫苗：aCIp的推荐，由医疗保健感染控制实践咨询委员会（HICpaC）支持，

Is the test for irreversibility of tetanus toxoids still relevant?

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