Recombinant H5 hemagglutinin adjuvanted with nanoemulsion protects ferrets against pathogenic avian influenza virus challenge

Wang Su He; Smith Douglas; Cao Zhengyi; Chen Jesse; Acosta Hugo; Chichester Jessica A.; Yusibov Vidadi; Streatfield Stephen J.; Fattom Ali; Baker James R. Jr.

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Recombinant H5 hemagglutinin adjuvanted with nanoemulsion protects ferrets against pathogenic avian influenza virus challenge

机译：重组H5血凝素均用纳米乳液施加，保护雪貂免受致病性禽流感病毒攻击

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Background: Highly pathogenic H5N1 influenza viruses remain a pandemic risk to the world population. Although vaccines are the best solution to prevent this threat, a more effective vaccine for H5 strains of influenza has yet to be developed. All existing vaccines target only serum antibody against influenza as the primary outcome, while mucosal immunity has not been addressed. To address these shortcomings we have used an effective mucosal adjuvant system to produce a prototype vaccine that provides antibody, cellular and mucosal immunity to multiple serotypes of H5.

机译：背景：高病原H5N1流感病毒仍然是世界人口的大流行风险。虽然疫苗是防止这种威胁的最佳解决方案，但尚未开发出更有效的血型流感菌株的疫苗。所有现有的疫苗只针对血清抗体免受流感的主要结果，而粘膜免疫尚未得到解决。为了解决这些缺点，我们使用了有效的粘膜佐剂系统来生产原型疫苗，为H5的多种血清型提供抗体，细胞和粘膜免疫。

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来源
《Vaccine》 |2019年第12期|共10页
作者
Wang Su He; Smith Douglas; Cao Zhengyi; Chen Jesse; Acosta Hugo; Chichester Jessica A.; Yusibov Vidadi; Streatfield Stephen J.; Fattom Ali; Baker James R. Jr.;
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作者单位

Univ Michigan Michigan Nanotechnol Inst Med &

Biol Sci M NIMBs Ann Arbor MI 48109 USA;

BlueWillow Biol Ann Arbor MI USA;

Univ Michigan Michigan Nanotechnol Inst Med &

Biol Sci M NIMBs Ann Arbor MI 48109 USA;

Univ Michigan Michigan Nanotechnol Inst Med &

Biol Sci M NIMBs Ann Arbor MI 48109 USA;

BlueWillow Biol Ann Arbor MI USA;

Fraunhofer USA Ctr Mol Biotechnol FhCMB Newark DE USA;

Fraunhofer USA Ctr Mol Biotechnol FhCMB Newark DE USA;

Fraunhofer USA Ctr Mol Biotechnol FhCMB Newark DE USA;

BlueWillow Biol Ann Arbor MI USA;

Univ Michigan Michigan Nanotechnol Inst Med &

Biol Sci M NIMBs Ann Arbor MI 48109 USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
H5N1; Nanoemulsion; Vaccine; Mice; Ferrets;

机译：H5N1;纳米乳剂;疫苗;小鼠;雪貂;

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专利

1. Recombinant H5 hemagglutinin adjuvanted with nanoemulsion protects ferrets against pathogenic avian influenza virus challenge [J] . Wang Su He, Smith Douglas, Cao Zhengyi, Vaccine . 2019,第12期

机译：重组H5血凝素均用纳米乳液施加，保护雪貂免受致病性禽流感病毒攻击
2. Live vaccination with an H5-hemagglutinin-expressing infectious laryngotracheitis virus recombinant protects chickens against different highly pathogenic avian influenza viruses of the H5 subtype. [J] . Pavlova S. P., Veits J., Mettenleiter T. C., Vaccine . 2009,第37期

机译：表达H5血凝素的感染性喉气管炎病毒重组体的活疫苗可以保护鸡免受H5亚型的不同高致病性禽流感病毒的侵害。
3. Protection against diverse highly pathogenic H5 avian influenza viruses in chickens immunized with a recombinant fowlpox vaccine containing an H5 avian influenza hemagglutinin gene insert. [J] . Swayne DE, Garcia M, Beck JR, Vaccine . 2000,第11a12期

机译：使用含有H5禽流感血凝素基因插入片段的重组鸡痘疫苗免疫的鸡，可预防多种高致病性H5禽流感病毒。
4. BIOSECURITY RISK FACTORS FOR HIGHLY PATHOGENIC AVIAN INFLUENZA(H5N8) VIRUS INFECTION IN DUCK FARMS, FRANCE [C] . Meeting of The Society^for^Veterinary^Epidemiology^and^Preventive^Medicine^(Great^Britain). . 2020

机译：法国鸭农场高病禽流感（H5N8）病毒感染的生物安全风险因素
5. Estimating evolutionary history and geographic spread of Highly Pathogenic Avian Influenza (HPAI) H5N1 virus. [D] . Manthena, Varuna. 2015

机译：估计高度致病性禽流感（HPAI）H5N1病毒的进化历史和地理分布。
6. Recombinant Parainfluenza Virus 5 Expressing Hemagglutinin of Influenza A Virus H5N1 Protected Mice against Lethal Highly Pathogenic Avian Influenza Virus H5N1 Challenge [O] . Zhuo Li, Alaina J. Mooney, Jon D. Gabbard, 2013

机译：表达重组甲型流感病毒H5N1血凝素的副流感病毒5保护小鼠免受致死性高致病性禽流感病毒H5N1挑战
7. Author Correction: A recombinant avian paramyxovirus serotype 3 expressing the hemagglutinin protein protects chickens against H5N1 highly pathogenic avian influenza virus challenge [O] . Edris Shirvani, Berin P. Varghese, Anandan Paldurai, 2020

机译：作者校正：表达血凝素蛋白的重组禽副磷病毒血清型3，血凝素蛋白保护鸡对H5N1高致病性禽流感病毒攻击

Recombinant H5 hemagglutinin adjuvanted with nanoemulsion protects ferrets against pathogenic avian influenza virus challenge

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