Tumor-associated antigens identified early in mouse mammary tumor development can be effective vaccine targets

Stanton Sasha E.; Gad Ekram; Corulli Lauren R.; Lu Hailing; Disis Mary L.

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Tumor-associated antigens identified early in mouse mammary tumor development can be effective vaccine targets

机译：在小鼠乳腺肿瘤发育早期鉴定的肿瘤相关抗原可以是有效的疫苗靶标

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Breast cancer vaccines composed of antigens identified by serological analysis of cDNA expression libraries (SEREX) induce antigen specific immune responses in patients but have had disappointing clinical benefits. While many attempts to modify the adjuvants and vaccine method have been tried, one issue not addressed was whether the SEREX tumor-associated antigens identified from late stages of disease were ideal targets. We questioned in the transgenic TgMMTV-neu mouse model whether the antigen repertoire is distinct between early and late stage breast cancer and whether the antigens identified via SEREX from transgenic mice with early or late stage tumors would elicit differential anti-tumor effects to address this question.

机译：由CDNA表达库（Serex）血清学分析鉴定的抗原组成的乳腺癌疫苗诱导患者抗原特异性免疫应答，但尚未令人失望的临床效益。虽然已经尝试了许多尝试修饰佐剂和疫苗方法，但没有解决的一个问题是从疾病的后期鉴定的Serex肿瘤相关抗原是理想的靶标。我们质疑在转基因TGMMTV-Neu鼠标模型中是否抗原曲目在早期和晚期乳腺癌之间是不同的，以及是否通过早期或晚期肿瘤的转基因小鼠通过Serex鉴定的抗原会引起差异的抗肿瘤效应来解决这个问题。

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来源
《Vaccine》 |2019年第27期|共10页
作者
Stanton Sasha E.; Gad Ekram; Corulli Lauren R.; Lu Hailing; Disis Mary L.;
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作者单位

Univ Washington Canc Vaccine Inst 850 Republican St Box 358050 Seattle WA 98109 USA;

Univ Washington Canc Vaccine Inst 850 Republican St Box 358050 Seattle WA 98109 USA;

Univ Washington Canc Vaccine Inst 850 Republican St Box 358050 Seattle WA 98109 USA;

Univ Washington Canc Vaccine Inst 850 Republican St Box 358050 Seattle WA 98109 USA;

Univ Washington Canc Vaccine Inst 850 Republican St Box 358050 Seattle WA 98109 USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Breast cancer prevention; Vaccine antigens; Th1; DNA vaccines; Mouse mammary tumor models;

机译：预防乳腺癌;疫苗抗原;TH1;DNA疫苗;小鼠乳腺肿瘤模型;

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专利

1. Tumor-associated antigens identified early in mouse mammary tumor development can be effective vaccine targets [J] . Stanton Sasha E., Gad Ekram, Corulli Lauren R., Vaccine . 2019,第27期

机译：在小鼠乳腺肿瘤发育早期鉴定的肿瘤相关抗原可以是有效的疫苗靶标
2. Venezuelan Equine Encephalitis Replicon Immunization Overcomes Intrinsic Tolerance and Elicits Effective Anti-tumor Immunity to the ‘Self’ tumor-associated antigen, neu in a Rat Mammary Tumor Model [J] . Edward L. Nelson, Darue Prieto, Terri G. Alexander, Breast Cancer Research and Treatment . 2003,第3期

机译：委内瑞拉马脑炎复制子免疫克服了内在耐受性，并在大鼠乳腺肿瘤模型中对“自我”肿瘤相关抗原neu产生了有效的抗肿瘤免疫力
3. DNA vaccines targeting tumor antigens to B7 molecules on antigen-presenting cells induce protective antitumor immunity and delay onset of HER-2/Neu-driven mammary carcinoma. [J] . Sloots A, Mastini C, Rohrbach F, Clinical cancer research: an official journal of the American Association for Cancer Research . 2008,第21期

机译：将肿瘤抗原靶向抗原呈递细胞上的B7分子的DNA疫苗可诱导保护性抗肿瘤免疫力，并延缓HER-2 / Neu驱动的乳腺癌的发作。
4. Optimized Immuno-affinity and LC-MS/MS Analysis of Tumor-Associated Antigen Peptides Derived from MAGE Proteins [C] . Darshit Shah, Xunbao Duan, Douglas MacDonald, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：优化的免疫亲和力和LC-MS / MS / MS分析衍生自MAGE蛋白的肿瘤相关抗原肽
5. Identification of novel MHC class I restricted tumor peptides antigens in mouse mammary tumors. [D] . Sypniewska, Roza Krystyna. 1997

机译：小鼠乳腺肿瘤中新型MHC I类限制性肿瘤肽抗原的鉴定。
6. Development of an Effective Cancer Vaccine Using Attenuated Salmonella and Type III Secretion System to Deliver Recombinant Tumor-Associated Antigens [O] . Xin Xu, Wael Abdel Halim Hegazy, Linjie Guo, -1

机译：利用减毒沙门氏菌和III型分泌系统提供重组肿瘤相关抗原的有效癌症疫苗的开发
7. Intraperitoneal administration of a tumor-associated antigen SART3, CD40L, and GM-CSF gene-loaded polyplex micelle elicits a vaccine effect in mouse tumor models. [O] . Kouichi Furugaki, Lin Cui, Yumi Kunisawa, 2014

机译：腹膜内施用肿瘤相关抗原saRT3，CD40L和Gm-CsF基因负载的聚合复合胶束在小鼠肿瘤模型中引发疫苗效应。
8. Venezuelan Equine Encephalitis Replicon Immunization Overcomes Intrinsic Tolerance and Elicits Effective Anti-Tumor Immunity to the 'Self' Tumor-Associated Antigen, neu in a Rat Mammary Tumor Model [R] . Nelson, E. L. , Prieto, D. , Alexander, T. G. , 2003

机译：委内瑞拉马脑炎复制子免疫在大鼠乳腺肿瘤模型中克服内在耐受并引发对“自身”肿瘤相关抗原，neu的有效抗肿瘤免疫

Tumor-associated antigens identified early in mouse mammary tumor development can be effective vaccine targets

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