Safety and immunogenicity of high-dose quadrivalent influenza vaccine in adults >= 65 years of age: A phase 3 randomized clinical trial

Chang Lee-Jah; Meng Ya; Janosczyk Helene; Landolfi Victoria; Talbot H. Keipp; Boone Gary; Briskin Toby; Cannon Kevin; Christensen Shane; Davis Matthew; Miel Emmanuel; Eck John; Essink Brandon; Finn Daniel; Fried David; Gorse Geoffrey; Griffin Carl; Hollister Ripley; Jacqmein Jeffry; Johnson Mark; Julien Katie; Kay Jennifer; Kirstein Judith; Koehler Timothy; Levin Michael; Martin Earl; Matherne Paul; Peterson James; Poling Terry; Saleh Jamshid; Segall Nathan; Seiden David; Strout Cynthia; Turner Mark; Varano Susann; Wilson Jonathan; Winkle Peter; Wombolt Duane; Abel Keshia; Babyak Jennifer; Bethuel Karine; Boyle Jacqueline; Broudic Karine; De Bruijn Iris; De Sousa Jennifer; Drago Erica; Flores Alma; Francis Deborah; Hicks Bryony; Fontvieille Anne-Isabelle; Hollingsworth Rosalind; Khoury Rawia; Lopez Denise; Lupinsky Nicole; Marshall Erik; Menard Lisa; Pandey Aseem; Patskan Viktor; Pekala David; Quinn Therese; Salamand Camille; Samson Sandrine; Seprish Mike; Setty Ramana; Urso Maxime; Wang Rose

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Safety and immunogenicity of high-dose quadrivalent influenza vaccine in adults >= 65 years of age: A phase 3 randomized clinical trial

机译：成人中高剂量四重型流感疫苗的安全性和免疫原性> = 65岁：第3期随机临床试验

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Background: A high-dose, split-virion inactivated trivalent influenza vaccine (IIV3-HD; Fluzone (R) High-Dose, Sanofi Pasteur) is available for adults >= 65 years of age. This study examined the safety and immunogenicity of a quadrivalent high-dose split-virion inactivated influenza vaccine (IIV4-HD).

机译：背景：高剂量，分裂病毒虫灭活三价流感疫苗（IIV3-HD;氟辛酮（R）高剂量，萨诺伊巴斯特）可用于成人> = 65岁。本研究检测了四价高剂量分裂病毒虫灭活流感疫苗的安全性和免疫原性（IIV4-HD）。

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《Vaccine》 |2019年第39期|共10页
作者
Chang Lee-Jah; Meng Ya; Janosczyk Helene; Landolfi Victoria; Talbot H. Keipp; Boone Gary; Briskin Toby; Cannon Kevin; Christensen Shane; Davis Matthew; Miel Emmanuel; Eck John; Essink Brandon; Finn Daniel; Fried David; Gorse Geoffrey; Griffin Carl; Hollister Ripley; Jacqmein Jeffry; Johnson Mark; Julien Katie; Kay Jennifer; Kirstein Judith; Koehler Timothy; Levin Michael; Martin Earl; Matherne Paul; Peterson James; Poling Terry; Saleh Jamshid; Segall Nathan; Seiden David; Strout Cynthia; Turner Mark; Varano Susann; Wilson Jonathan; Winkle Peter; Wombolt Duane; Abel Keshia; Babyak Jennifer; Bethuel Karine; Boyle Jacqueline; Broudic Karine; De Bruijn Iris; De Sousa Jennifer; Drago Erica; Flores Alma; Francis Deborah; Hicks Bryony; Fontvieille Anne-Isabelle; Hollingsworth Rosalind; Khoury Rawia; Lopez Denise; Lupinsky Nicole; Marshall Erik; Menard Lisa; Pandey Aseem; Patskan Viktor; Pekala David; Quinn Therese; Salamand Camille; Samson Sandrine; Seprish Mike; Setty Ramana; Urso Maxime; Wang Rose;
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作者单位

Sanofi Pasteur 1 Discovery Dr Swiftwater PA 18370 USA;

Sanofi Pasteur 1 Discovery Dr Swiftwater PA 18370 USA;

Sanofi Pasteur 1 Discovery Dr Swiftwater PA 18370 USA;

Sanofi Pasteur 1 Discovery Dr Swiftwater PA 18370 USA;

Vanderbilt Univ Med Ctr 1761 21st Ave South Nashville TN 37232 USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
High-dose influenza vaccine; Quadrivalent influenza vaccine; Elderly adults; Immunogenicity; Safety; Clinical trial;

机译：高剂量流感疫苗;四重血流感疫苗;老年人;免疫原性;安全;临床试验;

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专利

1. Safety and immunogenicity of high-dose quadrivalent influenza vaccine in adults >= 65 years of age: A phase 3 randomized clinical trial [J] . Chang Lee-Jah, Meng Ya, Janosczyk Helene, Vaccine . 2019,第39期

机译：成人中高剂量四重型流感疫苗的安全性和免疫原性> = 65岁：第3期随机临床试验
2. Immunogenicity, reactogenicity, and safety of inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine in healthy adults aged = 18 years: A phase III, randomized trial [J] . Tinoco Juan Carlos, Pavia-Ruz Noris, Cruz-Valdez Aurelio, Vaccine . 2014,第13期

机译：≥18岁健康成年人体内灭活的四价流感疫苗候选物与灭活的三价流感疫苗的免疫原性，反应原性和安全性：III期随机试验
3. Immunogenicity, reactogenicity and safety of an inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine: a phase III, randomized trial in adults aged ≥18?years [J] . Dorothee Kieninger, Eric Sheldon, Wen-Yuan Lin, BMC Infectious Diseases . 2013,第1期

机译：灭活的四价流感疫苗候选物与灭活的三价流感疫苗候选物的免疫原性，反应原性和安全性：一项针对18岁以上成年人的III期随机试验
4. A double-blind, randomized phase II trial of thesafety and immunogenicity of 26-valent group A streptococcus vaccine in healthy adults [C] . Shelly A. McNeil, Scott A. Halperin, Joanne M. Langley, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：一种双盲，随机期II试验，对健康成人的26岁的26岁群体的疫苗疫苗
5. Hypotensive resuscitation versus standard fluid resuscitation for the management of trauma patients in hemorrhagic shock: The safety phase of a randomized controlled trial. [D] . Morrison, C. Anne. 2009

机译：低血压复苏与标准液体复苏在失血性休克中对创伤患者的处理：一项随机对照试验的安全性阶段。
6. Immunogenicity and safety of high-dose quadrivalent influenza vaccine in Japanese adults ≥65 years of age: a randomized controlled clinical trial [O] . Leilani Sanchez, Osamu Matsuoka, Satoshi Inoue, 2020

机译：高剂量四价流感疫苗在≥65岁的日本成年人中的免疫原性和安全性：一项随机对照临床试验
7. Immunogenicity and safety of high-dose quadrivalent influenza vaccine in Japanese adults ≥65 years of age: a randomized controlled clinical trial [O] . Leilani Sanchez, Osamu Matsuoka, Satoshi Inoue, 2019

机译：日本成人高剂量四重血流感疫苗的免疫原性和安全性≥65岁：随机对照临床试验

Safety and immunogenicity of high-dose quadrivalent influenza vaccine in adults >= 65 years of age: A phase 3 randomized clinical trial

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