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The advances in brucellosis vaccines

机译：布鲁氏菌病疫苗的进展

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Brucellosis is a worldwide zoonosis affecting animal and human health. Till now, there is no effective vaccine licensed for brucellosis in humans. Although M5, H38 and 45/20 vaccines were used to prevent animal brucellosis in the early stages, the currently used animal vaccines are S19, Rev.1, S2, RB51 and SR82. However, these vaccines still have several drawbacks such as residual virulence and interfering conventional serological tests. With the development of DNA recombination technologies and the completion of the sequence of Brucella genome, much research focuses on the search for potential safer and more effective vaccines. Preliminary studies have demonstrated that new vaccines, including genetically engineered attenuated vaccines, subunit vaccines and other potential vaccines, have higher levels of protection, but there are still some problems. In this paper, we briefly review the main vaccines that have been used in controlling the brucellosis for decades and the progress in the development of new brucellosis vaccines. (C) 2019 Elsevier Ltd. All rights reserved.
机译：布鲁氏菌病是一种影响动物和人类健康的全球性病症。到目前为止，没有有效的疫苗用于人类的布鲁氏菌素。虽然M5，H38和45/20疫苗用于预防早期阶段的动物残疾，但目前使用的动物疫苗是S19，Rev.1，S2，RB51和SR82。然而，这些疫苗仍然具有若干缺点，例如残留的毒力和干扰常规血清学试验。随着DNA重组技术的发展和Brucella基因组序列的完成，很多研究侧重于寻找潜在更安全和更有效的疫苗。初步研究表明，新疫苗，包括转基因减毒疫苗，亚基疫苗和其他潜在疫苗，具有更高的保护水平，但仍存在一些问题。在本文中，我们简要介绍了用于控制布鲁克病的主要疫苗数十年，以及新的布鲁氏菌疫苗的发展进展。 （c）2019 Elsevier Ltd.保留所有权利。

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