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Comparison of vaccine effectiveness against influenza hospitalization of cell-based and egg-based influenza vaccines, 2017-2018

机译:疫苗效能对甲型流感植物疫苗治疗细胞和鸡蛋流感疫苗,2017-2018

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摘要

Egg-based influenza vaccines could be less effective than cell-based vaccine due to adaptive mutations acquired for growth. We conducted a test-negative case-control study at Kaiser Permanente Southern California to assess vaccine effectiveness (VE) against hospitalization for laboratory-confirmed influenza during 2017-2018. Among the 1186 cases and 6946 controls, 74% and 59%, respectively, were ages >= 65-years. For any influenza, the adjusted relative VE of cell-based vaccine versus egg-based vaccines was 43% (95% CI: -45% to 77%) for patients ages 65 years and 6% (95% CI: -46% to 39%) for patients ages >= 65-years. For influenza A(H3N2), the adjusted relative VE was 61% (95% CI: -63% to 91%) for patients ages 65 years and -4% (95% CI: -70% to 37%) for patients ages >= 65 years. Statistically significant protection against influenza hospitalization of cell-based vaccine compared to egg-based vaccines was not observed, but further studies in additional influenza seasons are warranted. (C) 2019 Published by Elsevier Ltd.
机译:由于获得生长的适应性突变,基于蛋的流感疫苗可能不如基于细胞的疫苗效果。在2017 - 2018年,我们在凯撒永久南加州进行了考试消极病例对照研究,以评估疫苗效力(VE)以防止2017 - 2018年的实验室证实流感的住院治疗。在1186例和6946例中,分别为74%和59%,均为> = 65岁。对于任何流感,对于患者年龄患者,基于细胞基疫苗的调整后的相对ve与蛋基疫苗与蛋疫苗为43%(95%CI:-45%至77%)。 65岁及6%(95%CI:-46%至39%),患者= 65岁。对于流感A(H3N2),调节的相对VE为患者年龄患者的61%(95%CI:-63%至91%),& 65岁和-4%(95%CI:-70%至37%),患者= 65岁。未观察到与鸡蛋的疫苗相比,对基于细胞基疫苗的统计学显着的保护,但不需要进一步研究额外的流感季节。 (c)2019年由elestvier有限公司发布

著录项

  • 来源
    《Vaccine》 |2019年第39期|共5页
  • 作者单位

    Kaiser Permanente Southern Calif Dept Res &

    Evaluat 100 S Los Robles Ave Pasadena CA 91101 USA;

    Kaiser Permanente Southern Calif Dept Res &

    Evaluat 100 S Los Robles Ave Pasadena CA 91101 USA;

    Kaiser Permanente Southern Calif Dept Res &

    Evaluat 100 S Los Robles Ave Pasadena CA 91101 USA;

    Kaiser Permanente Southern Calif Dept Res &

    Evaluat 100 S Los Robles Ave Pasadena CA 91101 USA;

    Kaiser Permanente Southern Calif Dept Res &

    Evaluat 100 S Los Robles Ave Pasadena CA 91101 USA;

    Seqirus Summit NJ USA;

    Kaiser Permanente Southern Calif Dept Res &

    Evaluat 100 S Los Robles Ave Pasadena CA 91101 USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    Influenza; Influenza vaccine; Vaccine effectiveness;

    机译:流感;流感疫苗;疫苗有效性;

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