UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments

Noad Rob J.; Simpson Karl; Fooks Anthony R.; Hewson Roger; Gilbert Sarah C.; Stevens Mark P.; Hosie Margaret J.; Prior Joann; Kinsey Anna M.; Entrican Gary; Simpson Andrew; Whitty Christopher J. M.; Carroll Miles W.

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UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments

机译：英国疫苗网络：映射流行病潜力和疫苗管道发展的优先级病原体

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During the 2013-2016 Ebola outbreak in West Africa an expert panel was established on the instructions of the UK Prime Minister to identify priority pathogens for outbreak diseases that had the potential to cause future epidemics. A total of 13 priority pathogens were identified, which led to the prioritisation of spending in emerging diseases vaccine research and development from the UK. This meeting report summarises the process used to develop the UK pathogen priority list, compares it to lists generated by other organisations (World Health Organisation, National Institutes of Allergy and Infectious Diseases) and summarises clinical progress towards the development of vaccines against priority diseases. There is clear technical progress towards the development of vaccines. However, the availability of these vaccines will be dependent on sustained funding for clinical trials and the preparation of clinically acceptable manufactured material during inter-epidemic periods.

机译：在2013-2016西非埃博拉疫情在西非爆发了一个专家小组，建立了英国总理的指示，以确定有可能导致未来流行病的疫情疾病的优先疾病。确定了13条优先级病原体，这导致了从英国出现新兴疾病疫苗研究和发展的开支的优先顺序。本次会议报告总结了用于开发英国病原体优先级列表的过程，将其与其他组织（世界卫生组织，国家过敏和传染病国家研究所）的列表进行比较，并总结了临床进展，以促进优先疾病的疫苗。疫苗的发展有明确的技术进步。然而，这些疫苗的可用性将依赖于临床试验的持续资金和在疫苗间流行期间制备临床可接受的制造材料。

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《Vaccine》 |2019年第43期|共7页
作者
Noad Rob J.; Simpson Karl; Fooks Anthony R.; Hewson Roger; Gilbert Sarah C.; Stevens Mark P.; Hosie Margaret J.; Prior Joann; Kinsey Anna M.; Entrican Gary; Simpson Andrew; Whitty Christopher J. M.; Carroll Miles W.;
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作者单位

Royal Vet Coll Pathobiol &

Populat Sci Hawkshead Lane Hatfield AL9 7TA Herts England;

JKS Biosci Ltd 2 Midanbury Court 44 Midanbury Lane Southampton SO18 4HF Hants England;

Anim &

Plant Hlth Agcy Weybridge Surrey England;

Publ Hlth England Natl Infect Serv Salisbury SP4 0JG Wilts England;

Univ Oxford Jenner Inst Old Rd Campus Res Bldg Oxford OX3 7DQ England;

Univ Edinburgh Sch Vet Studies Roslin Inst &

Royal Dick Easter Bush EH25 9RG Midlothian Scotland;

Univ Glasgow Ctr Virus Res MRC Coll Vet Med &

Life Sci Garscube Estate Glasgow G61 1QH Lanark Scotland;

Dstl Porton Down CBR Div Porton Down SP3 4DZ Wilts England;

MRC One Kemble St London WC2B 4AN England;

Pentlands Sci Pk Moredun Res Inst Near Edinburgh Penicuik EH26 0PZ Midlothian Scotland;

Publ Hlth England Natl Infect Serv Salisbury SP4 0JG Wilts England;

London Sch Hyg &

Trop Med Keppel St London WC1E 7HT England;

Publ Hlth England Natl Infect Serv Salisbury SP4 0JG Wilts England;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Vaccine; Epidemic; Priority; Pathogen; Outbreak; UKVN;

机译：疫苗;流行病;优先考虑;病原体;爆发;UKVN;

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专利

1. UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments [J] . Noad Rob J., Simpson Karl, Fooks Anthony R., Vaccine . 2019,第43期

机译：英国疫苗网络：映射流行病潜力和疫苗管道发展的优先级病原体
2. Analysis of Neglected Tropical Disease Drug and Vaccine Development Pipelines to Predict Issuance of FDA Priority Review Vouchers over the Next Decade [J] . Rianna Stefanakis, Andrew S. Robertson, Elizabeth L. Ponder, PLOS Neglected Tropical Diseases . 2012,第10期

机译：对被忽视的热带病药物和疫苗开发管道的分析，以预测下一个十年FDA优先审查凭证的发行
3. Potential Outer Membrane Protein Candidates for Vaccine Development Against the Pathogen Vibrio anguillarum: A Reverse Vaccinology Based Identification [J] . Baliga Pallavi, Shekar Malathi, Venugopal Moleyur Nagarajappa Current Microbiology: An International Journal . 2018,第3期

机译：潜在的外膜蛋白候选疫苗发育对病原体vibrio anguillarum：基于反向疫苗学的识别
4. PATHOGEN GENETIC DIVERSITY A CHALLENGE FOR VACCINE DEVELOPMENT: LOOKING FOR THE PATHOGEN'S ACHILLES' HEEL [C] . Ousmane A. Koita, Annie S. DeGroot Vaccine technology VI . 2016

机译：病原遗传多样性是疫苗发展的挑战：寻找病原菌的脚跟
5. Vaccines to combat meningococcal disease - definitive vaccines for elusive pathogens. [D] . Santos, George F. 2017

机译：对抗脑膜炎球菌疾病的疫苗-难以捉摸的病原体的确定性疫苗。
6. UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments [O] . Rob J. Noad, Karl Simpson, Anthony R. Fooks, -1

机译：英国疫苗网络：确定流行病的潜在病原体和疫苗开发计划
7. Analysis of neglected tropical disease drug and vaccine development pipelines to predict issuance of FDA priority review vouchers over the next decade. [O] . Rianna Stefanakis, Andrew S Robertson, Elizabeth L Ponder, 2012

机译：分析被忽视的热带病药物和疫苗开发管道，以预测未来十年FDa优先审查凭证的发放。

UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments

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