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首页> 外文期刊>Vaccine >Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus
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Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus

机译：疫苗介导的猪免受大流行H1N1 2009猪流感的感染保护病毒需要疫苗抗原和攻击病毒之间的密切抗原匹配

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摘要

Swine influenza A virus (SwIV) infection has considerable economic and animal welfare consequences and, because of the zoonotic potential, can also have public health implications. The 2009 pandemic H1N1 'swine-origin' infection is now endemic in both pigs and humans. In Europe, avian-like H1(av)N1, human-like H1(hu)N2, human-like swine H3N2 and, since 2009, pandemic H1N1 (pH1N1) lineage viruses and reassortants, constitute the dominant subtypes. In this study, we used a swine pH1N1 challenge virus to investigate the efficacy of whole inactivated virus vaccines homologous or heterologous to the challenge virus as well as a commercial vaccine. We found that vaccine-mediated protection was most effective when vaccine antigen and challenge virus were homologous and correlated with the specific production of neutralising antibodies and a cellular response to the challenge virus. We conclude that a conventional whole inactivated SwIV vaccine must be antigenically matched to the challenge strain to be an effective control measure. (C) 2019 Published by Elsevier Ltd.
机译：猪流感病毒（SWIV）感染具有相当大的经济和动物福利后果，而且由于人畜共患潜力，也可以具有公共卫生的影响。 2009年大流行H1N1'猪来源的感染现在是猪和人类的地方。在欧洲，禽样H1（AV）N1，人般的H1（HU）N2，人样猪H3N2，并且自2009年以来，大流行H1N1（PH1N1）谱系病毒和重配，构成了优势亚型。在这项研究中，我们使用了猪PH1N1攻击病毒来研究整个灭活病毒疫苗同源或异源对攻击病毒以及商业疫苗的疗效。我们发现当疫苗抗原和攻击病毒同源并与攻击病毒对攻击病毒的特异性产生和细胞反应相关的疫苗介导的保护最有效。我们得出结论，传统的整个灭活的SWIV疫苗必须抗原匹配，以攻击菌株是有效的控制措施。 （c）2019年由elestvier有限公司发布

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