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首页> 外文期刊>Vaccine >Effect of high and low levels of maternally derived antibodies on porcine circovirus type 2 (PCV2) infection dynamics and production parameters in PCV2 vaccinated pigs under field conditions
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Effect of high and low levels of maternally derived antibodies on porcine circovirus type 2 (PCV2) infection dynamics and production parameters in PCV2 vaccinated pigs under field conditions

机译：高低水平的潜水衍生抗体对猪循环系统型2（PCV2）感染动力学和在PCV2接种猪的疫苗疫苗中的影响

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摘要

The present study aimed to compare the efficacy of a porcine circovirus type 2 (PCV2) commercial vaccine in terms of average daily weight gain (ADWG) as well as infection dynamics in pigs with different maternally derived antibody (MDA) levels. A total of 337 animals from a PCV2 subclinically infected farm were distributed into two groups based on weight and PCV2 antibody levels (high [H] or low [L]) at 2 weeks of age. One week later, these animals were subdivided in four groups according to the treatment received. Vaccinated pigs (H-V and L-V) received 1 mL of a commercial vaccine and NV (H-NV and L-NV) received 1 mL of PBS. All piglets were subsequently bled at 7, 12, 18, 22 and 25 weeks of age and weighted at 12 and 25 weeks of age. V animals showed significantly lower PCV2 infection rates and viral load as well as higher ELISA S/P ratios and ADWG than NV ones. Compared with H-V piglets, L-V pigs showed numerically lower PCV2 infection rates, lower area under the curve of viral load, an earlier seroconversion and a numerically, but not significantly, higher ADWG. In this study, MDA did not seem to interfere with the effect of PCV2 vaccination on ADWG. However, only when a small subpopulation of pigs with the highest ELISA S/P ratios at vaccination was considered, an apparent interference of vaccine efficacy on ADWG was noticed. Therefore, the impact of the putative interference under field conditions is probably negligible for most farms. (C) 2016 Elsevier Ltd. All rights reserved.
机译：本研究旨在比较猪圆环病毒2（PCV2）商业疫苗在平均每日体重增加（ADWG）的疗效以及具有不同母体衍生抗体（MDA）水平的猪的感染动力学。在2周龄，基于重量和PCV2抗体水平（高[H]或低[L]）分布到两组中，将来自PCV2亚透视感染的农场的337只动物分发。一周后，这些动物根据收到的治疗细分四组细分。接种接种的猪（H-V和L-V）接受1ml的商业疫苗和NV（H-NV和L-NV）1mL PBS。随后将所有仔猪在年龄的7,12,18,22和25周内加入，并在12小时和25周的年龄加权。 v动物显示出显着降低PCV2感染率和病毒载荷以及比NV载体的更高的ELISA S / P比和ADWG。与H-V仔猪相比，L-V猪在数值下较低的PCV2感染率，病毒载荷曲线下的下部面积，早期的血清转换和数值，但不显着，更高的ADWG。在这项研究中，MDA似乎没有干扰PCV2疫苗接种对ADWG的影响。然而，只有当考虑在接种疫苗接种中具有最高ELISA S / P比的猪的小亚群时，注意到疫苗疗效对ADWG的表观干扰是注意的。因此，大多数农场可能会在现场条件下的推定干扰的影响可能是可忽略不计的。 （c）2016 Elsevier有限公司保留所有权利。

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