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Efficacy of various Marek's disease vaccines protocols for prevention of Marek's disease virus-induced immunosuppression

机译：各种MAREK疾病疫苗疫苗预防MAREK疾病病毒诱导的免疫抑制的疗效的疗效

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摘要

Marek's disease virus (MDV) induces tumors and severe immunosuppression in chickens. MDV-induced immunosuppression (MDV-IS) is very complex and difficult to study. In particular, the late MDV-IS (late-MDV-IS) is of great concern since it can occur in the absence of lymphoid organ atrophy or gross tumors. We have recently developed a model to reproduce late-MDV-IS under laboratory conditions. This model measures MDV-IS indirectly by assessing the effect of MDV infection on the efficacy of infectious laryngotracheitis (ILT) vaccination; hence the name late-MDV-IS ILT model. In this study, we have used the late-MDV-IS ILT model to evaluate if MD vaccination can protect against late-MDV-IS. One experiment was conducted to determine whether serotype 1 MD vaccines (CVI988 and Md5 Delta MEQ) could induce late-MDV-IS by themselves. Three additional experiments were conducted to evaluate efficacy of different MD vaccines (HVT, HVT+SB-1, CVI988, and Md5 Delta MEQ) and different vaccine protocols (day-old vaccination, in ovo vaccination, and double vaccination) against "late-MDV-IS. Our results show that none of the currently used vaccine protocols (HVT, HVT+SB-1, or CVI988 administered at day of age, in ovo, or in double vaccination protocols) protected against late-MDV-IS induced by vv+MDV strains 648A and 686. Experimental vaccine Md5 Delta MEQ administered subcutaneously at one day of age was the only vaccine protocol that significantly reduced late-MDV-IS induced by vv+MDV strain 686. This study demonstrates that currently used vaccine protocols confer high levels of protection against MDV-induced tumors (protection index = 100), but do not protect against late-MDV-IS; thus, commercial poultry flocks could suffer late-MDV-IS even in complete absence of tumors. Our results suggest that MDV-IS might not be related to the development of tumors and novel control methods are needed. Further evaluation of the experimental vaccine Md5 Delta MEQ might shed light on protective mechanisms against late-MDV-IS. (C) 2016 Elsevier Ltd. All rights reserved.
机译：Marek的疾病病毒（MDV）诱导鸡肿瘤和严重免疫抑制。 MDV诱导的免疫抑制（MDV-IS）非常复杂，难以研究。特别是，已故的MDV-是（晚期MDV-IS）非常关注，因为它可以在没有淋巴器官萎缩或粗糙肿瘤的情况下发生。我们最近开发了一种繁殖后期MDV的模型 - 是在实验室条件下。通过评估MDV感染对传染性喉痛炎（ILT）疫苗的疗效的影响，间接测量MDV-间接措施。因此，Laze-MDV的名称是ILL模型。在这项研究中，我们使用了后期MDV - 是ILT模型，以评估MD疫苗接种是否可以防止后期MDV-IS。进行了一个实验以确定血清型1MD疫苗（CVI988和MD5 Delta MEQ）是否可以自己诱导后期。进行了三种额外的实验以评估不同MD疫苗（HVT，HVT + SB-1，CVI988和MD5 DELTA MEQ）和不同疫苗方案（日龄疫苗接种，ovo疫苗接种和双重疫苗接种）的疗效对“晚期 - ” MDV-IS。我们的结果表明，在诱导后，目前疫苗的疫苗协议（在年龄的ovo或双疫苗接种方案中施用的HVT，HVT + SB-1或CVI988中没有诱导VV + MDV菌株648A和686.实验疫苗MD5 Delta MEQ在一天的一天皮下给药是唯一的疫苗方案，即由VV + MDV菌株686诱导显着降低的疫苗方案。该研究表明目前使用的疫苗协议赋予疫苗协议对MDV诱导的肿瘤的高水平保护（保护指数= 100），但不要防止后期的肿瘤 - 是;因此，商业家禽群可能遭受晚期 - 甚至完全没有肿瘤。我们的结果表明MDV-可能不相关D到肿瘤的发展和新的控制方法是必需的。进一步评价实验疫苗MD5 Delta Meq可能会对抗软化后MDV的保护机制脱光。 （c）2016 Elsevier有限公司保留所有权利。

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  • 来源
    《Vaccine》 |2016年第35期|共8页
  • 作者

    Faiz Nik M.; Cortes Aneg L.; Guy James S.; Fogle Jonathan E.; Gimeno Isabel M.;

  • 作者单位

    North Carolina State Univ Sch Vet Dept Populat Hlth &

    Pathobiol 1060 William Moore Dr Raleigh NC 27607 USA;

    North Carolina State Univ Sch Vet Dept Populat Hlth &

    Pathobiol 1060 William Moore Dr Raleigh NC 27607 USA;

    North Carolina State Univ Sch Vet Dept Populat Hlth &

    Pathobiol 1060 William Moore Dr Raleigh NC 27607 USA;

    North Carolina State Univ Sch Vet Dept Populat Hlth &

    Pathobiol 1060 William Moore Dr Raleigh NC 27607 USA;

    North Carolina State Univ Sch Vet Dept Populat Hlth &

    Pathobiol 1060 William Moore Dr Raleigh NC 27607 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    MDV; Control; ILTV; Immunosuppression; Immune system; Vaccine;

    机译：MDV;控制;ILTV;免疫抑制;免疫系统;疫苗;

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