...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Anti-glioma effect of intracranial vaccination with tumor cell lysate plus flagellin in mice
【24h】

Anti-glioma effect of intracranial vaccination with tumor cell lysate plus flagellin in mice

机译：肿瘤细胞裂解物加上小鼠颅骨疫苗术的抗胶瘤效应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The adjuvant effects of flagellin on regulation of immune response have been proved; whether flagellin could assist tumor cell lysate (TCL) to enhance anti-glioma immunity remains to be investigated. This study tests a hypothesis that therapeuticly intracranial administration with flagellin plus TCL enhances the effects of specific immunotherapy on glioma in mice. In this study, GL261 cells were transferred into C57BL/6 mice and the GL261-bearing mice were subcutaneously or intracranially inoculated with flagellin plus TCL, flagellin, TCL or saline. Our results showed that prophylacticly subcutaneous administration with TCL and flagellin could induce potent cytotoxic T lymphocyte (CTL) and prolong the survival of GL261-bearing mice significantly, but therapeuticly subcutaneous administration failed to. However, therapeuticly intracranial administration of TCL plus flagellin could prolong the survival. Moreover, intracranial administration of flagellin could recruit CD4(+) T cells and CD8(+) T cells to brain tissues, induce proliferation of natural killer (NK) cells, CD4(+) T cells and CD8(+) T cells in peripheral blood mononuclear cells and induce to splenomegaly. The results suggested that flagellin could be acted as an efficient adjuvant for TCL based vaccine. (C) 2018 Published by Elsevier Ltd.
机译：鞭毛蛋白对免疫反应调节的佐剂效应已得到证实;无论是鞭毛素是否可以帮助肿瘤细胞裂解物（TCL）以增强抗胶质瘤免疫仍有待研究。该研究试验，用鞭毛素加TCL治疗颅内给药的假设增强了特定免疫疗法对小鼠胶质瘤的影响。在本研究中，将GL261细胞转移到C57BL / 6小鼠中，并将GL261携带的小鼠皮下或甲虫接种用鞭毛蛋白加TCL，鞭毛蛋白，TCL或盐水。我们的研究结果表明，用TCL和鞭毛蛋白的预防性皮下给药可以诱导有效的细胞毒性T淋巴细胞（CTL），并显着延长GL261轴承小鼠的存活，但治疗皮下给药未能进行治疗。然而，TCL Plus鞭毛蛋白的治疗性颅内施用可以延长存活率。此外，颅骨颅内蛋白的颅内施用可以募集CD4（+）T细胞和CD8（+）T细胞至脑组织，诱导天然杀伤（NK）细胞，CD4（+）T细胞和CD8（+）T细胞在外周中的增殖血液单核细胞并诱导脾肿大。结果表明，鞭毛蛋白可以作为基于TCl的疫苗的有效佐剂。 （c）2018年由elestvier有限公司发布

著录项

  • 来源
    《Vaccine》 |2018年第52期|共10页
  • 作者

    Dong Boqi; Wang Liying; Nie Shu; Li Xin; Xiao Yue; Yang Lei; Meng Xiuping; Zhao Peiyan; Cui Cuiyun; Tu Liqun; Lu Wenting; Sun Wei; Yu Yongli;

  • 作者单位

    Jilin Univ Dept Immunol Coll Basic Med Sci Changchun Jilin Peoples R China;

    Jilin Univ Coll Basic Med Sci Dept Mol Biol Changchun Jilin Peoples R China;

    Jilin Univ Coll Basic Med Sci Dept Mol Biol Changchun Jilin Peoples R China;

    Jilin Univ Coll Basic Med Sci Dept Mol Biol Changchun Jilin Peoples R China;

    Jilin Univ Coll Basic Med Sci Dept Mol Biol Changchun Jilin Peoples R China;

    Jilin Univ Coll Basic Med Sci Dept Mol Biol Changchun Jilin Peoples R China;

    Jilin Univ Dept Immunol Coll Basic Med Sci Changchun Jilin Peoples R China;

    Jilin Univ Coll Basic Med Sci Dept Mol Biol Changchun Jilin Peoples R China;

    Jilin Univ Dept Immunol Coll Basic Med Sci Changchun Jilin Peoples R China;

    Jilin Univ Dept Immunol Coll Basic Med Sci Changchun Jilin Peoples R China;

    Jilin Univ Coll Basic Med Sci Dept Mol Biol Changchun Jilin Peoples R China;

    Jilin Univ Coll Basic Med Sci Dept Mol Biol Changchun Jilin Peoples R China;

    Jilin Univ Dept Immunol Coll Basic Med Sci Changchun Jilin Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    Tumor cell lysate; Flagellin; Vaccine; Adjuvant; Glioma;

    机译：肿瘤细胞裂解物;鞭毛;疫苗;佐剂;胶质瘤;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号