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Use of a new global indicator for vaccine safety surveillance and trends in adverse events following immunization reporting 2000-2015

机译:2000 - 2015年免疫报告后,使用新的全局指标进行疫苗安全监测和不良事件的趋势

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Reporting of adverse events following immunization (AEFI) is a key component for functional vaccine safety monitoring system. The aim of our study is to document trends in the AEFI reporting ratio globally and across the six World Health Organization (WHO) regions. We describe the number of AEFI reports communicated each year through the World Health Organization/United Nations Children's Fund Joint Reporting Form on Immunization from 2000 to 2015. The AEFI reporting ratios (annual AEFI reports per 100,000 surviving infants) were calculated to identify WHO countries (n = 191 in 2000 and n = 194 by 2015) that met a minimal reporting ratio of 10, a target set by the Global Vaccine Action Plan for vaccine safety monitoring as a proxy measure for a functional AEFI reporting system. The number of countries reporting any AEFI fluctuated over time but with progress from 32 (17%) in 2000 to 124 (64%) in 2015. In 2015, the global average AEFI reporting ratio was 549 AEFI reports per 100,000 surviving infants. The number of countries with AEFI reporting ratios greater than 10 increased from 8 (4%) in 2000 to 81 (42%) in 2015. In 2015, 60% of countries in the WHO Region of the Americas reported at least 10 AEFI per 100,000 surviving infants, followed by 55% in European Region, 43% in Eastern Mediterranean Region, 33% in Western Pacific Region, 27% in South-East Asia Region and 21% in African Region. Overall, AEFI reporting has increased over the past sixteen years worldwide, but requires strengthening in a majority of low- and middle-income countries. The AEFI reporting ratio is useful for benchmarking and following trends over time; but does not provide information on the quality of the reporting system and does not guarantee capacity to detect and manage a vaccine safety problem at a national level. Additional efforts are required to ensure and improve data quality, AEFI reporting and surveillance of immunization safety in every country. (C) 2018 World Health Organization; licensee Elsevier Ltd.
机译:免疫(AEFI)后不良事件的报告是功能疫苗安全监测系统的关键组成部分。我们的研究目的是通过全球和六个世界卫生组织(世卫组织)地区全球和六个世界卫生组织(WHO)地区的趋势记录趋势。我们描述了通过世界卫生组织/联合国儿童基金联合报告表于2000年至2015年免疫每年传达的AEFI报告数目。举行AEFI报告比率(每10万幸存婴儿的年度AEFI报告)以确定谁国家( N = 191在2000年和N = 194到2015年,符合最小的报告比例为10,通过全球疫苗行动计划为疫苗安全监测的全球疫苗行动计划提供的目标作为功能性AEFI报告系统的代理措施。报告任何AEFI的各国数量随着时间的推移而波动,但2015年的32人(17%)进展到124(64%)。2015年,全球平均AEFI报告率为549次幸存婴儿每10万人报告。 2015年的81%增加到10(4%)增加到81(4%)的国家数量增加到2015年的81(42%)。2015年,美国世界卫生组织地区的60%的国家报告每10万人至少有10个AEFI幸存婴儿,随后在欧洲地区55%,东地中海区43%,西太平洋地区33%,东南亚地区27%,非洲地区21%。总体而言,AEFI报告在全世界的十六年内增加,但需要加强大多数低收入和中等收入国家。 AEFI报告比率对于基准测试和趋势随着时间的推移而有用;但不提供有关报告系统质量的信息,并且不保证在国家一级检测和管理疫苗安全问题的能力。需要额外的努力来确保和改进每个国家的数据质量,AEFI报告和免疫安全监测。 (c)2018年世界卫生组织;被许可人elsevier有限公司

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