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Brucellosis vaccines based on the open reading frames from genomic island 3 of Brucella abortus

机译：基于Brucella Abortus的Genomic Island 3的开放阅读框架的Brucellosis疫苗

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Brucella abortus is the etiological agent of brucellosis, a zoonotic disease affecting cattle and humans. This disease has been partially controlled in cattle by immunization with live attenuated B. abortus S19 and RB51 strains. However, use of these vaccine strains has been associated with safety issues in animals and humans, New vaccines have since emerged in the prevention of brucellosis, particularly DNA vaccines, which have shown effectiveness and a good safety profile. Their protection efficacy in mice is associated with the induction of Th1 type and cytotoxic T cell mediated immune response against structural antigens and virulence factors expressed during B. abortus infection, Some antigenic candidate for vaccine design against brucellosis (mainly DNA vaccines) have been obtained from genomic island 3 (Gl-3) of B. abortus, which encodes several open reading frames (ORFs) involved in the intracellular survival and virulence of this pathogen. The immunogenicity and protection conferred by these DNA vaccines in a murine model is reviewed in this article, suggesting that some of them could be safe and effective vaccine candidates against to prevent B. abortus infection. (C) 2018 Elsevier Ltd. All rights reserved.
机译：Brucella abortus是Brucellosis的病因，一种影响牛和人类的动物疾病。该疾病通过用活病毒B.Abortius S19和RB51菌株免疫，在牛中部分控制。然而，使用这些疫苗菌株与动物和人类的安全问题有关，新疫苗出现在预防布鲁氏菌病，特别是DNA疫苗中，这些疫苗已经显示出有效性和良好的安全性。小鼠的保护功效与Th1型和细胞毒性T细胞介导的免疫应答诱导对抗结构抗原的免疫反应和B. Abortius感染期间表达的毒力因子，一些抗原疫苗设计的抗原候选者（主要是DNA疫苗）已经获得B. abortus的基因组岛3（GL-3），它​​们编码了涉及该病原体细胞内存活和毒力的几个开放阅读框架（ORF）。本文综述了这些DNA疫苗赋予了鼠模型中的免疫原性和保护，表明其中一些可能是安全有效的疫苗候选者，以防止B. Abortus感染。 （c）2018年elestvier有限公司保留所有权利。

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