A flagellin-adjuvanted PED subunit vaccine improved protective efficiency against PEDV variant challenge in pigs

Qianniu Li; Zhichao Xu; Tingting Wu; Ouyang Peng; Licheng Huang; Yun Zhang; Chunyi Xue; Zhifen Wen; Qingfeng Zhou; Yongchang Cao

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A flagellin-adjuvanted PED subunit vaccine improved protective efficiency against PEDV variant challenge in pigs

机译：鞭毛蛋白辅助PED亚基疫苗改善了猪的PEDV变异挑战的保护效率

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PEDV variants, causing severe diarrhea in neonatal suckling piglets with a mortality rate up to 100%, have being epidemic since late 2010 in china. To meet the pressing need of safe and cost-efficient PED maternal vaccines against PEDV variant, we vaccinated growing piglets with a flagellin-adjuvanted PED vaccine rSF-COE-3D by injection at Houhai acupoint. The vaccination not only enhanced the antibody responses of serum IgG/IgA, mucosal IgA and serum neutralizing antibody, but also improved the production of IFN-γ and IL-4. Moreover, rSF-COE-3D could provide a better protection against the challenge of a high pathogenic PEDV variant, with less diarrhea pigs, less pigs with detectable PEDV shed, lower rank values of feces and less apparent lesions and inflammation in duodenum of the PEDV infected pigs. The improved protective efficiency of rSF-COE-3D compared with COE was mostly benefited from the enhanced production of serum IgA, mucosal IgA in feces and serum neutralizing antibody titers. Taken together, our data suggest that rSF-COE-3D would be a novel efficient PED vaccine.

机译：PEDV变异性，导致新生儿哺乳仔猪的严重腹泻，死亡率高达100％，自2010年底以来陷入流行。为了满足对PEVV变体的安全和成本效益的PED母体疫苗的压迫需求，我们通过喷射在Houhah Acupopent中用鞭毛蛋白辅助的Ped疫苗RSF-Coe-3d疫苗接种仔猪。疫苗接种不仅增强了血清IgG / IgA，粘膜IGA和血清中和抗体的抗体应答，还改善了IFN-γ和IL-4的产生。此外，RSF-COE-3D可以更好地保护患有高病原PEVV变体的挑战，较少的腹泻猪，较少的猪，可检测的PEDV脱落，粪便较低等级值和较小的PEDENUM中的损伤和炎症。感染猪。与COE相比，RSF-COE-3D的改善保护效率主要受益于血清IgA，粪便中的血清IgA，粘膜IgA和血清中和抗体滴度的增强。我们的数据表明，我们的数据表明RSF-CoE-3D将是一种新型有效的PED疫苗。

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来源
《Vaccine》 |2018年第29期|共8页
作者
Qianniu Li; Zhichao Xu; Tingting Wu; Ouyang Peng; Licheng Huang; Yun Zhang; Chunyi Xue; Zhifen Wen; Qingfeng Zhou; Yongchang Cao;
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作者单位

State Key Laboratory of Biocontrol School of Life Science Sun Yat-sen University;

State Key Laboratory of Biocontrol School of Life Science Sun Yat-sen University;

State Key Laboratory of Biocontrol School of Life Science Sun Yat-sen University;

State Key Laboratory of Biocontrol School of Life Science Sun Yat-sen University;

State Key Laboratory of Biocontrol School of Life Science Sun Yat-sen University;

State Key Laboratory of Biocontrol School of Life Science Sun Yat-sen University;

State Key Laboratory of Biocontrol School of Life Science Sun Yat-sen University;

Guangdong Wenˊs Foodstuffs Group Co Ltd;

Guangdong Wenˊs Foodstuffs Group Co Ltd;

State Key Laboratory of Biocontrol School of Life Science Sun Yat-sen University;

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正文语种 other
中图分类医学免疫学;
关键词
Porcine epidemic diarrhea; Flagellin; Subunit vaccine; Protective efficiency;

机译：猪流行性腹泻;鞭毛蛋白;亚单位疫苗;保护效率;

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专利

1. A flagellin-adjuvanted PED subunit vaccine improved protective efficiency against PEDV variant challenge in pigs [J] . Qianniu Li, Zhichao Xu, Tingting Wu, Vaccine . 2018,第29期

机译：鞭毛蛋白辅助PED亚基疫苗改善了猪的PEDV变异挑战的保护效率
2. PED subunit vaccine based on COE domain replacement of flagellin domain D3 improved specific humoral and mucosal immunity in mice [J] . Li Qianniu, Peng Ouyang, Wu Tingting, Vaccine . 2018,第11期

机译：PED亚基疫苗基于COE结构域替代鞭毛蛋白域D3改善小鼠的特定体液和粘膜免疫力
3. Mucosal immunization with a flagellin-adjuvanted Hgp44 vaccine enhances protective immune responses in a murine Porphyromonas gingivalis infection model [J] . Puth Sao, Hong Seol Hee, Park Mi Jin, Human vaccines & immunotherapeutics. . 2017,第12期

机译：用鞭毛蛋白辅助HGP44疫苗免疫粘膜免疫疫苗在小鼠卟啉卟啉植物牙龈感染模型中增强了保护性免疫应答
4. Evaluation of the pathogenesis differences of the US PEDV prototype and S-INDEL-variant strains and examination of the cross-protective immunity of two strains in weaned pigs [C] . Qi Chen, Molly Stafne, Melisa Spadaro, Annual^Meeting of the American^Association^of^Swine^Veterinarians. . 2016

机译：评价美国PEDV原型和S-INDEL - 变异菌株的发病机制差异及两次断奶猪两种菌株的抗保护性抗保护性差异
5. Engineering CHO Cells to Improve the Quality and Immunogenicity of HIV Envelope Glycoprotein Subunit Vaccines [D] . Li, Sophia W. 2020

机译：工程CHO细胞提高HIV包膜糖蛋白亚群疫苗的质量和免疫原性
6. Novel Porcine Epidemic Diarrhea Virus (PEDV) Variants with Large Deletions in the Spike (S) Gene Coexist with PEDV Strains Possessing an Intact S Gene in Domestic Pigs in Japan: A New Disease Situation [O] . Nguyen Van Diep, Junzo Norimine, Masuo Sueyoshi, -1

机译：新型猪流行性腹泻病毒（PEDV）变异体中的穗状花序（S）基因大量缺失与在日本家猪中拥有完整S基因的PEDV菌株共存：一种新的疾病状况
7. Novel Porcine Epidemic Diarrhea Virus (PEDV) Variants with Large Deletions in the Spike (S) Gene Coexist with PEDV Strains Possessing an Intact S Gene in Domestic Pigs in Japan: A New Disease Situation. [O] . Nguyen Van Diep, Junzo Norimine, Masuo Sueyoshi, 2017

机译：新型猪流行性腹泻病毒（pEDV）变异与穗（s）基因大量缺失共存与pEDV株在日本国内猪中具有完整的s基因：一种新的疾病情况。
8. CpG Oligodeoxynucleotide and Montanide ISA 51 Adjuvant Combination Enhanced the Protective Efficacy of a Subunit Malaria Vaccine [R] . Kumar, S. , Jones, T. R. , Oakley, M. S. , 2004

机译：CpG寡脱氧核苷酸和montanide Isa 51佐剂组合增强了亚单位疟疾疫苗的保护效力

A flagellin-adjuvanted PED subunit vaccine improved protective efficiency against PEDV variant challenge in pigs

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