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首页> 外文期刊>Vaccine >Response to pneumococcal vaccine in interstitial lung disease patients: Influence of systemic immunosuppressive treatment
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Response to pneumococcal vaccine in interstitial lung disease patients: Influence of systemic immunosuppressive treatment

机译：间质肺病患者的肺炎球菌疫苗的反应：全身免疫抑制治疗的影响

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摘要

BackgroundInterstitial lung diseases (ILD) are severe respiratory diseases, and ILD patients are treated with corticosteroid and immunosuppressive agents. However, it is unclear whether these medications influence the response of pneumococcal vaccine.ObjectivesWe examined the immunogenicity of pneumococcal vaccines (PPSV23 and PCV13) in ILD patients undergoing immunosuppressive treatment.MethodsILD patients who were regularly followed at the outpatient clinic were enrolled. Sera were collected before and 4–8?weeks after vaccination. Serotype-specific immunoglobulin G (IgG) concentrations against pneumococcal serotype 19F were measured by ELISA.ResultsIgG concentrations to serotype 19F were increased in all groups in response to the vaccine. Both PCV13 and PPSV23 induced IgG concentrations in patients immunized for the first time. Response rates for the ILD group were comparable with those for the ILD group undergoing corticosteroid therapy. Only idiopathic pulmonary fibrosis patients undergoing immunosuppressive therapy had a significantly lower response.
机译：体积肺疾病（ILD）是严重的呼吸系统疾病，患者用皮质类固醇和免疫抑制剂治疗。然而，目前尚不清楚这些药物是否会影响肺炎球菌疫苗的反应。objectiveWe检测到肺炎球菌疫苗（PPSv23和PCV13）的免疫原性在接受免疫抑制治疗的患者中。纳入门诊诊所定期遵循的患者。在疫苗接种后收集血清和4-8周。通过ELISA.Resultsigg浓度测量血清型免疫球蛋白G（IgG）抑制抗肺炎球菌血管型19F的浓度，响应于疫苗，所有基团的血液浓度为血清型19F。 PCV13和PPSV23均在第一次免疫的患者中诱导IgG浓度。 ILD组的反应率与遭受皮质类固醇治疗的ILD组的响应率相当。只有经常性肺纤维化患者接受免疫抑制治疗的反应显着降低。

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  • 来源
    《Vaccine》 |2018年第33期|共5页
  • 作者

    Koji Kuronuma; Hiroyuki Honda; Tessei Mikami; Atsushi Saito; Kimiyuki Ikeda; Mitsuo Otsuka; Hirofumi Chiba; Gen Yamada; Toyotaka Sato; Shin-ichi Yokota; Hiroki Takahashi;

  • 作者单位

    Department of Respiratory Medicine and Allergology Sapporo Medical University School of Medicine;

    Department of Respiratory Medicine and Allergology Sapporo Medical University School of Medicine;

    SANWA Clinic;

    Department of Respiratory Medicine and Allergology Sapporo Medical University School of Medicine;

    Department of Respiratory Medicine and Allergology Sapporo Medical University School of Medicine;

    Department of Respiratory Medicine and Allergology Sapporo Medical University School of Medicine;

    Department of Respiratory Medicine and Allergology Sapporo Medical University School of Medicine;

    Department of Respiratory Medicine and Allergology Sapporo Medical University School of Medicine;

    Department of Microbiology Sapporo Medical University School of Medicine;

    Department of Microbiology Sapporo Medical University School of Medicine;

    Department of Respiratory Medicine and Allergology Sapporo Medical University School of Medicine;

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  • 正文语种 other
  • 中图分类 医学免疫学;
  • 关键词

    Pneumococcal vaccine; Interstitial lung diseases; Idiopathic pulmonary fibrosis; Immunosuppressive;

    机译：肺炎球菌疫苗;间质性肺病;特发性肺纤维化;免疫抑制;

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