Innovative approaches to track lymph node germinal center responses to evaluate development of broadly neutralizing antibodies in human HIV vaccine trials

M. Patricia DSouza; Mary A. Allen; Jane A.G. Baumblatt; Cesar Boggiano; Shane Crotty; Christine Grady; Colin Havenar-Daughton; Antje Heit; Dale J. Hu; Nina Kunwar; M. Juliana McElrath; Lymph Node Webinar Contributors

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Innovative approaches to track lymph node germinal center responses to evaluate development of broadly neutralizing antibodies in human HIV vaccine trials

机译：追踪淋巴结发芽中心反应的创新方法，以评估人艾滋病病毒疫苗试验中广泛中和抗体的发展

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Phase 1 clinical studies will soon evaluate novel HIV-1 envelope immunogens targeting distinct ‘germline’ and memory B cell receptors to ultimately elicit HIV-1 broadly neutralizing antibodies (bNAbs). The National Institute of Allergy and Infectious Diseases (NIAID) recently convened a panel of US-based expert scientists, clinicians, sponsors and ethicists to discuss the role of sampling draining lymph nodes within preventive HIV vaccine trials. The meeting addressed the importance of evaluating germinal center (GC) responses following immunization to predict bNAb potency and breadth, and reviewed key aspects of this procedure within the clinical research setting, including informed consent, adverse event monitoring, study participant acceptability, medical expertise and training. We review highlights from the meeting and discuss the advantages and disadvantages of sampling lymph nodes by excisional biopsies compared to fine needle aspirations (FNA) in the context of prophylactic HIV vaccine trials.

机译：第1项阶段临床研究将很快评估新的HIV-1包膜免疫原靶向不同“种系”和记忆B细胞受体，以最终引导学生HIV-1广泛中和抗体（bNAbs）。过敏和传染病研究所（NIAID）全国学院最近召开的总部设在美国专家的科学家，医生，赞助商和伦理学家的小组讨论预防性HIV疫苗试验中取样引流淋巴结的作用。会议讨论评估免疫接种预测bNAb效力和广度，以及临床研究环境中此过程的审查主要方面，包括知情同意，不良事件监测，研究参与者接受，医学专业知识生发中心（GC）反应的重要性，训练。我们回顾从会议的亮点和讨论相比，在预防性艾滋病疫苗试验的背景下细针穿刺（FNA）通过切除活检取样淋巴结的优点和缺点。

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《Vaccine》 |2018年第38期|共7页
作者
M. Patricia DSouza; Mary A. Allen; Jane A.G. Baumblatt; Cesar Boggiano; Shane Crotty; Christine Grady; Colin Havenar-Daughton; Antje Heit; Dale J. Hu; Nina Kunwar; M. Juliana McElrath; Lymph Node Webinar Contributors;
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作者单位

Division of AIDS NIAID;

Division of AIDS NIAID;

Division of AIDS NIAID;

Division of AIDS NIAID;

Division of Vaccine Discovery La Jolla Institute for Allergy and Immunology;

Department of Bioethics NIH;

Division of Vaccine Discovery La Jolla Institute for Allergy and Immunology;

Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center;

Division of AIDS NIAID;

Division of AIDS NIAID;

Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center;

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正文语种 other
中图分类医学免疫学;
关键词
HIV vaccines; Lymph node biopsies; Clinical immune monitoring;

机译：HIV疫苗;淋巴结活检;临床免疫监测;

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专利

1. Innovative approaches to track lymph node germinal center responses to evaluate development of broadly neutralizing antibodies in human HIV vaccine trials [J] . M. Patricia DSouza, Mary A. Allen, Jane A.G. Baumblatt, Vaccine . 2018,第38期

机译：追踪淋巴结发芽中心反应的创新方法，以评估人艾滋病病毒疫苗试验中广泛中和抗体的发展
2. Putative rhesus macaque germline predecessors of human broadly HIV-neutralizing antibodies: Differences from the human counterparts and implications for HIV-1 vaccine development [J] . Yuan Tingting, Li Jingjing, Zhang Yu, Vaccine . 2011,第40期

机译：人类广泛中和抗体的假定恒河猴猕猴种系的前身：与人类对应物的差异及其对HIV-1疫苗开发的影响
3. Report of the Cent Gardes HIV Vaccine Conference the B-cell response to HIV. Part 1: Broadly neutralizing antibodies Fondation Merieux Conference Center, Veyrier du Lac, France, 5-7 November 2012. [J] . Girard M. P., Picot V., Longuet C., Vaccine . 2013,第29期

机译：Cent Gardes HIV疫苗会议的报告B细胞对HIV的反应。第1部分：广泛中和抗体2012年11月5日至7日，法国Veyrier du Lac基金会Merieux会议中心。
4. COMBINING NOVEL AND TRADITIONAL APPROACHES OF VACCINE DEVELOPMENT TO OVERCOME THE CHALLENGES OF FIRST-IN-HUMAN TRIAL FOR GROUP A STREPTOCOCCUS [C] . Elodie Burlet, Anisa Dunham, Harm HogenEsch, Conference on vaccine technology VI . 2018

机译：结合疫苗开发的新方法和传统方法来克服链球菌首次人为试验的挑战
5. Broadly Neutralizing Antibodies and Broadly Neutralizing Sera: Insights into HIV-1 Vaccine Design [D] . Walker, Laura M. 2011

机译：广泛中和抗体和广泛中和血清：对HIV-1疫苗设计的见解
6. Putative rhesus macaque germline predecessors of human broadly HIV-neutralizing antibodies: differences from the human counterparts and implications for HIV-1 vaccine development [O] . Tingting Yuan, Jingjing Li, Yu Zhang, -1

机译：人类宽艾滋病毒中和抗体的推定恒河猴种系前位：与人类对应的差异和HIV-1疫苗发育的影响
7. Putative rhesus macaque germline predecessors of human broadly HIV-neutralizing antibodies: Differences from the human counterparts and implications for HIV-1 vaccine development [O] . Wang, Y, Zhang, Y, Li, J, 2011

机译：人类广泛HIV中和抗体的推定恒河猴猿种系前身：与人类对应物的差异以及对HIV-1疫苗开发的影响

Innovative approaches to track lymph node germinal center responses to evaluate development of broadly neutralizing antibodies in human HIV vaccine trials

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