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Identification of determinants associated with uptake of the first dose of the human papillomavirus vaccine in Denmark

机译：鉴定丹麦人乳头瘤病毒疫苗的吸收相关的决定因素

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BackgroundThe human papillomavirus vaccine (HPV vaccine) was introduced into the Danish Childhood Vaccination Programme in 2009. Following a national debate questioning the safety of the vaccine, the coverage decreased from an uptake of >90% for the first dose of the HPV vaccine to an uptake of 52% in girls born in 2003. The aim of this study was to identify changes in determinants for HPV vaccine hesitancy in the period when the debate spiraled and to identify determinants for specific hesitancy towards the HPV vaccine among girls who received the second dose of the measles, mumps and rubella vaccine.MethodsWe included girls born in the period 1999–2003 who were residing in Denmark between their 12th and 13th birthday (n?=?161,528). Data from the Danish Vaccination Register were linked with demographic data from the Danish Civil Registration System. We used multiple logistic regression models to identify associations between determinants and the uptake of the first dose of the HPV vaccine (HPV1).ResultsFor girls born in 1999–2000, low uptake was seen in children of increasing birth order, young or old age of mother, non-Danish origin, low uptake of other childhood vaccines, and in girls living with one parent. For girls born in 2001–2003, most of these determinants of low uptake became less significant. Birth order and origin showed different tendencies when comparing birth cohorts 1999–2000 with birth cohorts 2001–2003.ConclusionsWe found demographic disparities in the uptake of HPV1 that were generally in line with existing literature. More importantly, the results indicate that determinants for hesitancy towards the HPV vaccines changed during a period of intense public debate regarding the safety of the HPV vaccine. This may indicate that the public concerns over safety disproportionally affect those who trusted vaccines prior to the debate.
机译：背景技术人乳头瘤病毒疫苗（HPV疫苗）于2009年引入丹麦儿童疫苗接种计划。在国家辩论质疑疫苗的安全性后，覆盖率从110％的摄取量降低了HPV疫苗的第一个剂量在2003年出生的女孩中摄取了52％。本研究的目的是在螺旋螺旋的辩论和鉴定对接受第二剂的女孩的女孩的HPV疫苗的特异性犹豫不决的时期，确定HPV疫苗犹豫不决的决定因素的变化麻疹，腮腺炎和风疹疫苗。近奇地区包括1999年至2003年期间出生的女孩，他们在12日和13岁生日之间居住在丹麦（n？= 161,528）之间。来自丹麦疫苗接种寄存器的数据与来自丹麦民事登记系统的人口统计数据相关联。我们使用多元逻辑回归模型来识别决定因素之间的关联和第一剂HPV疫苗（HPV1）的摄取。从1999 - 2000年出生的女孩出生的女孩，在增加出生秩序，年轻或年龄的儿童中被观察到低摄取母亲，非丹麦起源，低吸收其他童年疫苗，以及与一个父母一起生活的女孩。对于在2001 - 2003年出生的女孩来说，这些低摄取的大多数决定簇变得不太重要。出生秩序和起源在将1999-2000与出生队列2001-2003的出生队列比较时趋势和原产地显示了不同的趋势.Conclusionswe发现了一般与现有文献一致的HPV1摄取中的人口差异。更重要的是，结果表明，在关于HPV疫苗的安全的激烈的公众辩论期间，决定因素改变了HPV疫苗。这可能表明，公众对安全的担忧不成比例地影响辩论之前有信任疫苗的人。

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