Safety and immunogenicity of inactivated poliovirus vaccine made from Sabin strains: A phase II, randomized, dose-finding trial

Chu Kai; Ying Zhifang; Wang Ling; Hu Yuansheng; Xia Jielai; Chen Lei; Wang Jianfeng; Li Changgui; Zhang Qian; Gao Qiang; Hu Yuemei

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Safety and immunogenicity of inactivated poliovirus vaccine made from Sabin strains: A phase II, randomized, dose-finding trial

机译：由Sabin菌株制成的灭活脊髓灰质炎疫苗的安全性和免疫原性：II期，随机化，剂量寻找试验

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Background: In order to completely eradicate polio caused by wild poliovirus infection as well as vaccine-associated paralytic polio (VAPP), Sabin inactivated poliovirus vaccine (sIPV) should be developed to meet the requirements for biosafety and affordable strategy in the developing countries.

机译：背景：为了完全根除由野生脊髓灰质炎病毒感染和疫苗相关的瘫痪脊髓灰质炎（vApp）引起的脊髓灰质炎，应制定Sabin灭活的脊髓灰质病毒疫苗（SIPV），以满足发展中国家的生物安全和实惠策略的要求。

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《Vaccine》 |2018年第45期|共8页
作者
Chu Kai; Ying Zhifang; Wang Ling; Hu Yuansheng; Xia Jielai; Chen Lei; Wang Jianfeng; Li Changgui; Zhang Qian; Gao Qiang; Hu Yuemei;
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作者单位

Jiangsu Prov Ctr Dis Control &

Prevent 172 Jiangsu Rd Nanjing 210009 Jiangsu Peoples R China;

Natl Inst Food &

Drug Control Beijing Peoples R China;

Fourth Mil Med Univ Xian Shaanxi Peoples R China;

Sinovac Biotech Co LTD 39 Shangdi West Rd Beijing 100085 Peoples R China;

Fourth Mil Med Univ Xian Shaanxi Peoples R China;

Pizhou Cty Ctr Dis Control &

Prevent Pizhou Jiangsu Peoples R China;

Natl Inst Food &

Drug Control Beijing Peoples R China;

Natl Inst Food &

Drug Control Beijing Peoples R China;

Sinovac Biotech Co LTD 39 Shangdi West Rd Beijing 100085 Peoples R China;

Sinovac Biotech Co LTD 39 Shangdi West Rd Beijing 100085 Peoples R China;

Jiangsu Prov Ctr Dis Control &

Prevent 172 Jiangsu Rd Nanjing 210009 Jiangsu Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Sabin strains; Inactivated poliovirus vaccine; Phase II clinical trial; Safety; Immunogenicity;

机译：Sabin菌株;灭活的脊髓灰质病毒疫苗;II期临床试验;安全;免疫原性;

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专利

1. Safety and immunogenicity of inactivated poliovirus vaccine made from Sabin strains: A phase II, randomized, dose-finding trial [J] . Chu Kai, Ying Zhifang, Wang Ling, Vaccine . 2018,第45期

机译：由Sabin菌株制成的灭活脊髓灰质炎疫苗的安全性和免疫原性：II期，随机化，剂量寻找试验
2. Safety and Immunogenicity of Inactivated Poliovirus Vaccine Made From Sabin Strains: A Phase II, Randomized, Positive-Controlled Trial [J] . Guoyang Liao12a Rongcheng Li3a Changgui Li4a Mingbo Sun12 Yanping Li3 Jiayou Chu12 Shude Jiang12a and Qihan Li12 Journal of Infectious Diseases . 2012,第2期

机译：萨宾菌株制成的灭活脊髓灰质炎疫苗的安全性和免疫原性：II期，随机，阳性对照试验
3. Immunogenicity and safety of different sequential schedules of Sabin strain-based inactivated poliovirus vaccination: A randomized, controlled, open-label, phase IV clinical trial in China [J] . Yan Shaohong, Chen Haiping, Zhang Zhenguo, Vaccine . 2020,第40期

机译：基于Sabin菌株的灭活脊髓灰质炎疫苗接种的不同顺序调度的免疫原性和安全性：中国的随机，受控，开放标签，中国临床临床试验
4. A double-blind, randomized phase II trial of thesafety and immunogenicity of 26-valent group A streptococcus vaccine in healthy adults [C] . Shelly A. McNeil, Scott A. Halperin, Joanne M. Langley, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：一种双盲，随机期II试验，对健康成人的26岁的26岁群体的疫苗疫苗
5. Surveillance of immunity acquired from poliovirus immunization including vaccination with the Sabin strain-derived inactivated vaccine [D] . HOTTA, Chiemi 2019

机译：脊髓灰质炎病毒免疫获得的免疫力的监测，包括用萨宾菌株衍生的灭活疫苗接种
6. Safety and Immunogenicity of Sabin Strain Inactivated Poliovirus Vaccine Compared With Salk Strain Inactivated Poliovirus Vaccine in Different Sequential Schedules With Bivalent Oral Poliovirus Vaccine: Randomized Controlled Noninferiority Clinical Trials in China [O] . Yuemei Hu, Kangwei Xu, Weixiao Han, 2019

机译：Sabin株灭活脊髓灰质炎疫苗与Salk株灭活脊髓灰质炎疫苗的安全性和免疫原性在不同的二价口服脊髓灰质炎疫苗连续接种日程中：中国随机对照非劣效性临床试验
7. Safety and Immunogenicity of Inactivated Poliovirus Vaccine Made From Sabin Strains: A Phase II, Randomized, Positive-Controlled Trial [O] . Guoyang Liao, Rongcheng Li, Changgui Li, 2011

机译：由Sabin菌株制成的灭活脊髓灰质炎疫苗的安全性和免疫原性：II期，随机，阳性对照试验

Safety and immunogenicity of inactivated poliovirus vaccine made from Sabin strains: A phase II, randomized, dose-finding trial

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