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首页> 外文期刊>Vaccine >Global burden of diarrheal diseases among children in developing countries: Incidence, etiology, and insights from new molecular diagnostic techniques
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Global burden of diarrheal diseases among children in developing countries: Incidence, etiology, and insights from new molecular diagnostic techniques

机译：发展中国家儿童腹泻疾病的全球负担：新分子诊断技术的发病率，病因和见解

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The Global Enteric Multicenter Study (GEMS) demonstrated that Shigella and enterotoxigenic Escherichia coli (ETEC) producing heat stable toxin (ST) (either alone or in combination with heat labile toxin) are among the most important pathogens associated with moderate-to-severe diarrhea (MSD) in children younger than 5 years of age living in developing countries. To inform the design of vaccines and other interventions, we reviewed published data and new results from GEMS characterizing the burden of Shigella and ST-ETEC infections. Clinical parameters were assessed to examine the value of various case definitions as indicators of MSD associated with Shigella and ST-ETEC for use in clinical trials. We discussed advantages and disadvantages of culture-based and culture-independent molecular diagnostics for detecting clinically and epidemiologically relevant disease. Shigella serotyping data from GEMS were examined to identify desirable components of Shigella and ETEC vaccines likely to confer broad protection. These findings can inform the development and implementation of vaccines to prevent these important infections among infants and children in developing countries. (C) 2017 Published by Elsevier Ltd.
机译：全球肠溶式多中心研究（Gems）展示了志贺氏菌和肠毒素大肠杆菌（ETEC）生产热稳定的毒素（ST）（单独或与热不稳定毒素组合）是与中度至严重的腹泻相关的最重要病原体中（MSD）在居住在发展中国家5岁以下的儿童。为了告知设计疫苗和其他干预措施，我们审查了表征志贺和ST-ETEC感染负担的宝石的发布数据和新结果。评估临床参数以检查各种情况定义的价值作为与志贺氏菌和ST-ETEC相关的MSD指标，用于临床试验。我们讨论了培养基和培养无关的分子诊断的优缺点，用于检测临床和流行病学相关疾病。研究了来自宝石的Shigella血清型数据，以确定可能赋予广泛保护的志贺氏菌和ETEC疫苗的理想成分。这些发现可以为疫苗的开发和实施提供信息，以防止发展中国家婴儿和儿童之间的这些重要感染。 （c）2017年由elestvier有限公司出版

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