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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Degradable pH-responsive NIR-II imaging probes based on a polymer-lanthanide composite for chemotherapy
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Degradable pH-responsive NIR-II imaging probes based on a polymer-lanthanide composite for chemotherapy

机译：基于聚合物 - 镧系元素复合材料进行化学疗法的可降解的pH-响应NIR-II成像探针

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In this research, a pH-sensitive degradable nanoprobe was designed by combining hydrophobic rare earth nanoparticles with biocompatible mPEG-PLGA nanomicelles for near infrared II (NIR-II) imaging-guided anti-tumor chemotherapy. The as-synthesized nanoprobes (about 300 nm) with a highly enhanced permeability and retention (EPR) effect show great potential in the diagnosis of solid tumors, providing new prospects for clinical tumor diagnosis. Then, the degradable composite probes increase the imaging sensitivity of the probe and allow for the slow release of the internal anti-tumor drugs, reducing the loss of the drug during delivery. Finally, ultra-small rare earth nanoparticles (about 6 nm) can be excreted after hydrolysis of the composite probe to reduce the enrichment of the inorganic nanoparticlesin vivo. Thus, this degradable NIR-II imaging probe based on a polymer-lanthanide composite could be a promising candidate for preclinical cancer chemotherapy and surgery navigation under a single 808 nm laser.
机译：在这项研究中，对pH敏感的可降解的纳米探针是由疏水性的稀土类纳米粒子与生物相容的mPEG-PLGA纳米胶束为近红外II（NIR-II）成像引导抗肿瘤化疗组合设计。所合成的纳米探针（约300纳米）具有高度增强的渗透性和保留（EPR）效果显示在实体瘤的诊断潜力很大，提供用于临床肿瘤的诊断新的前景。然后，可降解复合探针增加探头的成像灵敏度，并且允许内部抗肿瘤药物的缓慢释放，从而减少输送过程中药物的损失。最后，超小型稀土的纳米粒子（约6nm）可在复合探针的水解之后被排泄减少无机nanoparticlesin体内的富集。因此，基于聚合物 - 镧系元素复合物这可降解NIR-II成像探针可以是用于临床前癌症化疗和手术导航有希望的候选单808 nm的激光下。

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