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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Copper(ii)-based coordination polymer nanofibers as a highly effective antibacterial material with a synergistic mechanism
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Copper(ii)-based coordination polymer nanofibers as a highly effective antibacterial material with a synergistic mechanism

机译：基于铜（II）的配位聚合物纳米纤维，作为具有协同机制的高效抗菌材料

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Nanofibers of a copper(ii)-based coordination polymer [Cu(HBTC)(H2O)(3)] were synthesized via a microwave-assisted hydrothermal process, while macroparticles and bulk crystals were prepared via a hydrothermal method. X-ray analysis revealed that this compound possesses one-dimensional zig-zag chains, in which the coordination polyhedron of the copper(ii) center is a five-coordinate distorted square-pyramid. The width of the as-prepared nanofibers was about 150 nm, while the size of the macroparticles was about 200 mu m. The antibacterial activities of the nanofibers and macroparticles against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were evaluated by determining the minimal inhibitory concentration (MIC), the growth curve of the bacteria and the bacterial reduction assay. The nanofibers showed higher antibacterial performance as compared with macroparticles, commercial copper nanoparticles, and pure ligands alone. The bacteriostatic rates of nanofibers and macroparticles were up to 99.9% and 96.7% against E. coli, while 99.1% and 96.2% against S. aureus, respectively, when the concentration was 250 mu g mL(-1). The synergistic antibacterial mechanism was also proposed based on the generation of reactive oxygen species (ROS) and the release of Cu2+ ions.
机译：通过微波辅助水热法合成铜（II）的铜（II）的配位聚合物[Cu（HBTC）（H2O）（3）]，而通过水热法制备宏颗粒和散装晶体。 X射线分析显示，该化合物具有一维之曲线链，其中铜（II）中心的协调多面体是一个五坐标扭曲的方形金字塔。制备的纳米纤维的宽度约为150nm，而大颗粒的尺寸约为200μm。通过测定最小抑制浓度（MIC），细菌的生长曲线和细菌还原测定来评估纳米纤维和抗大肠杆菌（大肠杆菌）和金黄色葡萄球菌的抗菌活性的抗菌活性和金黄色葡萄球菌。与Macrocally，商业铜纳米粒子和单独的纯配体相比，纳米纤维显示出更高的抗菌性能。纳米纤维和宏颗粒的抑菌率高于大肠杆菌上的99.9％和96.7％，而分别浓度为250μmgmm（-1）时，分别针对金黄色葡萄球菌的99.1％和96.2％。还基于产生活性氧物质（ROS）和Cu 2 +离子的释放的协同抗菌机理。

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    Raf Abdul; Ye Junwei; Zhang Siqi; Qi Ye; Wang Guangyao; Che Ying; Ning Guiting;

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    Dalian Univ Technol State Key Lab Fine Chem 2 Linggong Rd Dalian 116024 Peoples R China;

    Dalian Univ Technol State Key Lab Fine Chem 2 Linggong Rd Dalian 116024 Peoples R China;

    Dalian Univ Technol State Key Lab Fine Chem 2 Linggong Rd Dalian 116024 Peoples R China;

    Dalian Univ Technol State Key Lab Fine Chem 2 Linggong Rd Dalian 116024 Peoples R China;

    Dalian Univ Technol State Key Lab Fine Chem 2 Linggong Rd Dalian 116024 Peoples R China;

    Dalian Med Univ Affiliated Hosp 1 Dept Ultrasound 193 Lianhe Rd Dalian 116011 Liaoning Peoples R China;

    Dalian Univ Technol State Key Lab Fine Chem 2 Linggong Rd Dalian 116024 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;无机化学;
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