Development and characterization of lanthanide-HPDO3A-C16-based micelles as CEST-MRI contrast agents

Ferrauto Giuseppe; Beauprez Frederik; Di Gregorio Enza; Carrera Carla; Aime Silvio; Terreno Enzo; Delli Castelli Daniela

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Development and characterization of lanthanide-HPDO3A-C16-based micelles as CEST-MRI contrast agents

机译：镧系元素-HPDO3A-C16胶束作为CEST-MRI造影剂的发展与表征

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The synthesis and characterization of a novel HPDO3A-based ligand having a C16 alkyl chain and its Eu3+, Gd3+ and Yb3+ complexes are reported. These amphiphilic paramagnetic complexes can form micelles with very good stability both in phosphate buffer and in human serum. A high number of Ln-complexes (ca. 200 molecules) are present in the micelle, providing this system with good sensitivity (M in terms of micelle concentration) for MRI detection. Moreover, it has been found that the cell toxicity of the micelles may be reduced by adding DSPE-PEG2000 in the formulation. Both relaxometric and CEST properties of the micelles were investigated in detail. The micelles loaded with Eu- and Yb-HPDO3A complexes, similar to what was reported for the water-soluble analogs, act as pH-sensors and appear to be suitable for CEST multicolor experiments.

机译：报道了具有C16烷基链及其EU3 +，GD3 +和YB3 +复合物的新型HPDO3A基配体的合成和表征。这些两亲的顺磁性复合物可以在磷酸盐缓冲液和人血清中形成具有非常好的稳定性的胶束。胶束中存在大量的LN-复合物（CA.200分子），为MRI检测提供具有良好敏感性（米胶浓度浓度的m的系统。此外，已经发现，通过在制剂中添加DSPE-PEG2000，可以减少胶束的细胞毒性。详细研究了胶束的弛豫和CEST性质。加载有Eu-and Yb-HPDO3A配合物的胶束，类似于报道的水溶性类似物的内容，作为pH传感器，似乎适用于CEST多色实验。

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《Dalton transactions: An international journal of inorganic chemistry》 |2019年第16期|共9页
作者
Ferrauto Giuseppe; Beauprez Frederik; Di Gregorio Enza; Carrera Carla; Aime Silvio; Terreno Enzo; Delli Castelli Daniela;
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Univ Torino Mol Imaging Ctr Dept Mol Biotechnol &

Hlth Sci Via Nizza 52 I-10126 Turin IT Italy;

Univ Torino Mol Imaging Ctr Dept Mol Biotechnol &

Hlth Sci Via Nizza 52 I-10126 Turin IT Italy;

Univ Torino Mol Imaging Ctr Dept Mol Biotechnol &

Hlth Sci Via Nizza 52 I-10126 Turin IT Italy;

Univ Torino Mol Imaging Ctr Dept Mol Biotechnol &

Hlth Sci Via Nizza 52 I-10126 Turin IT Italy;

Univ Torino Mol Imaging Ctr Dept Mol Biotechnol &

Hlth Sci Via Nizza 52 I-10126 Turin IT Italy;

Univ Torino Mol Imaging Ctr Dept Mol Biotechnol &

Hlth Sci Via Nizza 52 I-10126 Turin IT Italy;

Univ Torino Mol Imaging Ctr Dept Mol Biotechnol &

Hlth Sci Via Nizza 52 I-10126 Turin IT Italy;

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正文语种 eng
中图分类化学;无机化学;
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1. Development and characterization of lanthanide-HPDO3A-C16-based micelles as CEST-MRI contrast agents [J] . Ferrauto Giuseppe, Beauprez Frederik, Di Gregorio Enza, Dalton transactions: An international journal of inorganic chemistry . 2019,第16期

机译：镧系元素-HPDO3A-C16胶束作为CEST-MRI造影剂的发展与表征
2. Synthesis and characterization of SPIO-loaded PEG-b-PS micelles as contrast agent for long-term nanoparticle-based MRI phantom [J] . MAN THEERASILP, WITAYA SUNGKARAT, NORASED NASONGKLA Bulletin of materials science . 2018,第2期

机译：SPIO负载的PEG-b-PS胶束的合成和表征，作为基于纳米颗粒的长期MRI体模的造影剂
3. Synthesis and characterization of SPIO-loaded PEG-b-PS micelles as contrast agent for long-term nanoparticle-based MRI phantom [J] . MAN THEERASILP, WITAYA SUNGKARAT, NORASED NASONGKLA Bulletin of materials science . 2018,第2期

机译：SPIO负载的PEG-b-PS胶束的合成和表征，作为基于纳米颗粒的长期MRI体模的造影剂
4. Development of Theranostic Polymeric Micelles Incorporating Anticancer Drugs and MRI Contrast Agents [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：掺入抗癌药物和MRI造影剂的治疗聚合物胶束的发展
5. Development and characterization of hollow polymeric microcapsules for use as contrast agents for diagnostic ultrasound. [D] . Narayan, Padma Jyothi. 1999

机译：中空聚合物微胶囊的开发和表征，用作诊断超声的造影剂。
6. The development and characterization of a novel yet simple 3D printed tool to facilitate phantom imaging of photoacoustic contrast agents [O] . Santiago J. Arconada-Alvarez, Jeanne E. Lemaster, Junxin Wang, 2017

机译：新型但简单的3D打印工具的开发和表征可促进光声造影剂的幻像成像
7. Synthesis and characterization of SPIO-loaded PEG-b-PS micelles as contrast agent for long-term nanoparticle-based MRI phantom [O] . Man Theerasilp, Witaya Sungkarat, Norased Nasongkla 2018

机译：基于长期纳米粒子基MRI幻影的Spoa-Labored PEG-B-PS胶束的合成与表征

Development and characterization of lanthanide-HPDO3A-C16-based micelles as CEST-MRI contrast agents

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