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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >A recyclable post-synthetically modified Al(iii) based metal-organic framework for fast and selective fluorogenic recognition of bilirubin in human biofluids
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A recyclable post-synthetically modified Al(iii) based metal-organic framework for fast and selective fluorogenic recognition of bilirubin in human biofluids

机译：基于合成的合成改性的Al（III）金属有机框架，用于在人生物流体中的胆红素的快速和选择性荧光识别

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摘要

Herein, we report the fast and selective detection of bilirubin by a recyclable Al(iii) based post-synthetically modified MIL-53 metal-organic framework (MOF) (1-NH2@THB). Post-synthetic modification was achieved by the aldimine condensation reaction between MIL-53-NH2 and 2,3,4-trihydroxy benzaldehyde. The post-synthetically modified compound was successfully characterized by Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric (TG) analysis and X-ray powder diffraction (XRPD) experiments. The material has huge potential to detect bilirubin in HEPES buffer medium (pH = 7.4) by a fluorescence turn-off mechanism. The drastic quenching in the fluorescence emission intensity of the MOF material in the presence of bilirubin is due to the inner filter effect as well as molecular interactions between the MOF material and bilirubin. The probe displayed ultra-fast response (30 s), low detection limit (1.26 pM) and high selectivity towards bilirubin with the co-existence of several metal ions and biomolecules. Moreover, the real field application of the probe was thoroughly investigated in human bio-fluids (blood serum and urine samples) by the standard addition method. Furthermore, the quenching ability of the MOF material by bilirubin was also explored on a portable paper strip device. All the above discussions indicate that the probe is a potential candidate for the clinical detection of jaundice.
机译：在此，我们通过基于合成的综合改性的MIL-53金属 - 有机框架（MOF）（1-NH2 @ THB）来报告胆红素的快速和选择性地检测胆红素。通过MIL-53-NH2和2,3,4-三羟基苯苯甲醛之间的醛摩金缩合反应实现了合成后修饰。通过傅里叶变换红外（FT-IR）光谱，热重分析（TG）分析和X射线粉末衍射（XRPD）实验成功地表征了合成后改性化合物。通过荧光关断机构，该材料具有巨大的潜力在HEPES缓冲培养基（pH = 7.4）中检测胆红素。胆红素存在下MOF材料的荧光发射强度的激烈猝灭是由于内部滤波器效应以及MOF材料和胆红素之间的分子相互作用。探头显示超快速响应（30秒），低检测限（1.26mP）和对胆红素的高选择性，与几种金属离子和生物分子的共存。此外，通过标准添加方法在人生物流体（血液血清和尿液样本）中彻底研究了探针的真实野外施用。此外，在便携式纸条装置上还探索了胆红素的MOF材料的淬火能力。所有上述讨论表明探针是临床检测黄疸的潜在候选者。

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