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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Copper(ii) complexes with NNO ligands: synthesis, crystal structures, DNA cleavage, and anticancer activities
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Copper(ii) complexes with NNO ligands: synthesis, crystal structures, DNA cleavage, and anticancer activities

机译：铜（II）铜（II）与NNO配体的复合物：合成，晶体结构，DNA裂解和抗癌活性

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Three novel copper(ii) complexes, Cu(L1)(2) (1), Cu(L2)(2)2DMF (2), and Cu(L3)(2)2DMF (3), were synthesized using three aroylhydrazone ligands, (E)-2-hydroxy-N '-(1-(pyrazin-2-yl)ethylidene)benzohydrazide (HL1), (E)-3-hydroxy-N '-(1-(pyrazin-2-yl)ethylidene)benzohydrazide (HL2) and (E)-4-hydroxy-N '-(1-(pyrazin-2-yl)ethylidene)benzohydrazide (HL3). The complexes were characterized by elemental analysis, infrared (IR), and Ultraviolet-visible light (UV-vis) spectroscopy. The X-ray crystal structures of the complexes all possess a distorted octahedral coordination geometry. Both an absorption spectral titration and a competitive binding assay (ethidium bromide, 4 ',6-diamidino-2-phenylindole (DAPI), and methyl green) revealed that complexes 2 and 3 bind readily to calf thymus DNA (ctDNA) through intercalative and minor groove binding modes. Complexes 2 and 3 also exhibited oxidative cleavage of supercoiled plasmid DNA (pUC19) in the presence of ascorbic acid as an activator. Cytotoxicity studies showed that complexes 2 and 3 possessed high cytotoxicities toward the HeLa human cervical cancer cell line, but weak toxicities toward the L929 normal mouse fibroblast cell line. We therefore have reason to believe that complexes 2 and 3 both show potential as promising anticancer candidate drugs.
机译：三种新型铜（II）配合物，Cu（L1）（2）（1），Cu（L2）（2）2DMF（2）和Cu（L3）（2）2DMF（3）用三种芳酰肼配体合成，合成，（e）-2-羟基-N' - （1-（吡嗪-2-基）亚乙基）苯并酰肼（HL1），（E）-3-羟基-N' - （1-（吡嗪-2-基）亚乙基肼（HL2）和（E）-4-羟基-N' - （1-（吡嗪-2-基）亚乙基）苯并肼（HL 3）。通过元素分析，红外（IR）和紫外线可见光（UV-VI）光谱，该配合物的特征在于。复合物的X射线晶体结构都具有扭曲的八面体配位几何形状。吸收光谱滴定和竞争结合测定（溴化乙锭，4'，6-二脒基-2-苯基吲哚（DAPI）和甲基绿）揭示了复合物2和3通过内嵌性和含量粘合到CALF胸腺DNA（CTDNA）结合较小的凹槽绑定模式。复合物2和3还在抗坏血酸作为活化剂存在下表现出超氧化硅脂DNA（PUC19）的氧化切割。细胞毒性研究表明，复合物2和3对Hela人宫颈癌细胞系具有高细胞毒性，但朝向L929正常小鼠成纤维细胞系弱毒性。因此，我们有理由相信复合体2和3都表现为有前途的抗癌候选药物。

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    Yang Ping; Zhang Dan-Dan; Wang Zi-Zhou; Liu Hui-Zhong; Shi Qing-Shan; Xie Xiao-Bao;

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    Guangdong Acad Sci Guangdong Prov Key Lab Microbial Culture Collect State Key Lab Appl Microbiol Southern China Guangdong Inst Microbiol Guangdong Open Lab Appl Guangzhou 510070 Peoples R China;

    Guangdong Acad Sci Guangdong Prov Key Lab Microbial Culture Collect State Key Lab Appl Microbiol Southern China Guangdong Inst Microbiol Guangdong Open Lab Appl Guangzhou 510070 Peoples R China;

    Guangzhou Univ Sch Chem &

    Chem Engn Guangzhou Higher Educ Mega Ctr 230 Wai Huan Xi Rd Guangzhou 510006 Peoples R China;

    Guangdong Acad Sci Guangdong Prov Key Lab Microbial Culture Collect State Key Lab Appl Microbiol Southern China Guangdong Inst Microbiol Guangdong Open Lab Appl Guangzhou 510070 Peoples R China;

    Guangdong Acad Sci Guangdong Prov Key Lab Microbial Culture Collect State Key Lab Appl Microbiol Southern China Guangdong Inst Microbiol Guangdong Open Lab Appl Guangzhou 510070 Peoples R China;

    Guangdong Acad Sci Guangdong Prov Key Lab Microbial Culture Collect State Key Lab Appl Microbiol Southern China Guangdong Inst Microbiol Guangdong Open Lab Appl Guangzhou 510070 Peoples R China;

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