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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Effective loading of cisplatin into a nanoscale UiO-66 metal-organic framework with preformed defects
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Effective loading of cisplatin into a nanoscale UiO-66 metal-organic framework with preformed defects

机译：有效地将顺铂载入纳米级UIO-66金属有机骨架，预制缺陷

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摘要

Defects within the nanoscale UiO-66 metal-organic framework (MOF) are created to lock a hybrid phosphonoacetate ligand through Zr-O-P linkages, leaving the carboxyl group free to anchor cisplatin prodrug cis, cis, trans-[Pt(NH3)(2)Cl-2(OH)(2)]. A drug loading of 256.5 mg g(-1) (25.7 wt% based on cisplatin) was achieved with a Zr-6:Pt:P ratio of 1.5:1:1, which surpasses defect-free UiO-66 and several other MOF carriers. This framework exhibited a burst release of its payload in PBS solution in the first 2 h, releasing 71% of the drug, including a 50% payload release in less than 1 h. This work demonstrates that MOF defects can be intentionally engineered to achieve a high drug loading, and serves as an alternative to drug encapsulation using the pore void and through the association of the functionalized ligand.
机译：纳米级UIO-66金属 - 有机框架（MOF）内的缺陷是通过Zr-op键锁定杂化膦酰乙酸酯配体，使羧基可自由锚定锚固顺铂前药CIS，CIS，Trans-[Pt（NH3）（2 ）CL-2（OH）（2）]。 使用Zr-6：Pt：P比率为1.5：1：1，达到256.5mg G（-1）（基于顺铂的25.7wt％的药物负载量，超过1.5：1：1，其超越无缺陷的UIO-66和其他几种MOF 载体。 该框架在前2小时内展示了其PBS溶液中其有效载荷的突发释放，释放了71％的药物，包括50％的有效载荷释放，小于1小时。 这项工作表明，可以有意地设计MOF缺陷以实现高药物载荷，并用作使用孔隙空隙和通过官能化配体的缔合物的药物包封的替代品。

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    Lin Shi-Xin; Pan Wei-Lun; Niu Ru-Jie; Liu Yan; Chen Jin-Xiang; Zhang Wen-Hua; Lang Jian-Ping; Young David J.;

  • 作者单位

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci Suzhou 215123 Peoples R China;

    Southern Med Univ Guangdong Prov Key Lab New Drug Screening Sch Pharmaceut Sci Guangzhou 510515 Guangdong Peoples R China;

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci Suzhou 215123 Peoples R China;

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci Suzhou 215123 Peoples R China;

    Southern Med Univ Guangdong Prov Key Lab New Drug Screening Sch Pharmaceut Sci Guangzhou 510515 Guangdong Peoples R China;

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci Suzhou 215123 Peoples R China;

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci Suzhou 215123 Peoples R China;

    Charles Darwin Univ Coll Engn Informat Technol &

    Environm Darwin NT 0810 Australia;

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  • 正文语种 eng
  • 中图分类 化学;无机化学;
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