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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Copper(ii) complexes with 2,2 ':6 ',2 ''-terpyridine, 2,6-di(thiazol-2-yl)pyridine and 2,6-di(pyrazin-2-yl)pyridine substituted with quinolines. Synthesis, structure, antiproliferative activity, and catalytic activity in the oxidation of alkanes and alcohols with peroxides
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Copper(ii) complexes with 2,2 ':6 ',2 ''-terpyridine, 2,6-di(thiazol-2-yl)pyridine and 2,6-di(pyrazin-2-yl)pyridine substituted with quinolines. Synthesis, structure, antiproliferative activity, and catalytic activity in the oxidation of alkanes and alcohols with peroxides

机译：铜（II）配合物，具有2,2'：6'，2'' - 吡啶，2,6-二（噻唑-2-基）吡啶和2,6-二（吡嗪-2-基）吡啶被喹啉取代 。 用过氧化物氧化烷烃和醇的合成，结构，抗增殖活性和催化活性

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A series of 2,2 ':6 ',2 ''-terpyridine (terpy), 2,6-di(thiazol-2-yl)pyridine (dtpy) and 2,6-di(pyrazin-2-yl)pyridine (dppy) derivatives with n-quinolyl substituents (n = 2 and 4) was used to synthesize five-coordinate complexes [CuCl2(n-quinolyl-terpy)] (1-2), [CuCl2(n-quinolyl-dtpy)] (3-4) and [CuCl2(n-quinolyl-dppy)] (5-6), respectively. The main emphasis of the research was to investigate the impact of the triimine skeleton (terpy, dtpy and dppy) and n-quinolyl pendant substituent on the antiproliferative and catalytic properties of 1-6. The obtained Cu(ii) compounds were studied as antiproliferative agents against human colorectal (HCT116) and ovarian (A2780) carcinoma, and they were used as catalysts for the oxidation of alkanes and alcohols with peroxides under mild conditions. The kinetic characteristics of the oxidizing species generated by the catalytic system Cu(ii) complex-H2O2 in CH3CN were obtained from the dependence of the alkane oxidation rate on its initial concentration. A model of competitive interaction of hydroxyl radicals with CH3CN and RH in the catalyst cavity has been proposed which is based on the simultaneous study of kinetics and selectivity in alkane oxidations.
机译：一系列2,2'：6'，2'' - 吡啶（Terpy），2,6-二（噻唑-2-基）吡啶（DTPY）和2,6-二（Pyrazin-2-基）吡啶（DPPY）具有N-喹啉取代基（n = 2和4）的衍生物用于合成五坐标络合物[CuCl 2（n-喹啉基）]（1-2），[CuCl2（n-inInolyl-dtpy）] （3-4）和[CuCl2（N-喹啉基-DPPY）]（5-6）。研究的主要重点是研究三咪木骨架（TERPY，DTPY和DPPY）和N-喹啉基侧链取代基对1-6的抗增殖和催化性质的影响。将所得Cu（II）化合物作为抗增殖剂进行抗增殖剂（HCT116）和卵巢癌（A2780）癌，它们用作在温和条​​件下用过氧化物氧化烷烃和醇的催化剂。由催化体系Cu（II）复合物-H2O2在CH 3C中产生的氧化物质的动力学特性从烷烃氧化率的初始浓度的依赖性获得。提出了催化剂腔中CH3CN和RH羟基自由基竞争相互作用的模型，其基于同时研究动力学和烷烃氧化中的选择性。

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