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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Interfacially synthesized Fe-soc-MOF nanoparticles combined with ICG for photothermal/photodynamic therapy
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Interfacially synthesized Fe-soc-MOF nanoparticles combined with ICG for photothermal/photodynamic therapy

机译:界面合成的Fe-SoC-MOF纳米颗粒与ICG联合光热/光动力治疗

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摘要

Recently, fabrication of nanoscale MOFs (NMOFs) has attracted great attention for biomedical applications. NMOFs not only maintain the structural diversity and physicochemical properties of bulk MOFs, but also possess suitable dimensions, making them potential nanocarriers for imaging agents and drug molecules. In this work, highly monodispersed Fe-soc-MOF nanoparticles (about 100 nm) were fabricated through the liquid-solid-solution (LSS) method. Indocyanine green (ICG) was conjugated to the surface-modified Fe-soc-MOF to construct a multifunctional theranostic platform. The Fe-soc-MOF@PEG-NH2-ICG nanoparticles (FPINs) were tested for photothermal therapy (PTT)/photodynamic therapy (PDT) both in vitro and in vivo. Due to their low toxicity, good biocompatibility and excellent photothermal/photodynamic effect, the as-synthesized FPINs could be used to inhibit and kill cancer cells efficiently under the 808 nm laser irradiation.
机译:最近,纳米级MOF(NMOFS)的制作引起了生物医学应用的极大关注。 NMOFS不仅维持散装MOF的结构分集和物理化学性质,而且具有合适的尺寸,使它们具有用于成像剂和药物分子的潜在纳米载体。 在这项工作中,通过液体 - 固溶体(LSS)法制造高度单分散的Fe-SoC-MOF纳米颗粒(约100nm)。 吲哚菁绿(ICG)与表面改性的Fe-SoC-MOF缀合,以构建多功能治疗平台。 在体外和体内测试Fe-SoC-Mof @ PEG-NH2-ICG纳米颗粒(Fpins)以进行光热疗(PTT)/光动力治疗(PDT)。 由于它们的毒性低,生物相容性良好和优异的光热/光动力学效果,可以使用且合成的Fpins在808nm激光照射下有效地抑制和杀死癌细胞。

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    Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Rare Earth Resource Utilizat Changchun 130022 Jilin Peoples R China;

    Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Rare Earth Resource Utilizat Changchun 130022 Jilin Peoples R China;

    Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Rare Earth Resource Utilizat Changchun 130022 Jilin Peoples R China;

    Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Rare Earth Resource Utilizat Changchun 130022 Jilin Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;无机化学;
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