A biocompatible metal-organic framework as a pH and temperature dual-responsive drug carrier

Lin Wenxin; Cui Yuanjing; Yang Yu; Hu Quan; Qian Guodong

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A biocompatible metal-organic framework as a pH and temperature dual-responsive drug carrier

机译：一种生物相容性金属有机框架作为pH和温度双响应药物载体

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A biocompatible metal-organic framework Zn-GA comprising zinc ions and the bio-friendly molecule l-glutamic acid (GA) is synthesized as a drug delivery system, and controlled drug release triggered by pH and thermal stimuli without premature delivery is realized. The anticancer drug methotrexate (MTX) is selected to be encapsulated into the crystal which possesses one-dimensional channels along the a axis. The on-command drug carrier shows superior biocompatibility, extremely low toxicity, satisfactory loading capabilities and excellent dual-responsiveness, indicating its practical application as an efficient drug carrier with controlled release.

机译：包含锌离子和生物友好分子L-谷氨酸（Ga）的生物相容性金属 - 有机框架Zn-Ga作为药物递送系统合成，并实现了通过pH和热刺激而没有过早递送的受控药物释放。选择抗癌药物甲氨蝶呤（MTX）将封装在晶体中，该晶体沿轴线具有一维通道。在指挥药物载体上显示出优异的生物相容性，极低的毒性，令人满意的负载能力和优异的双响应性，表明其作为具有受控释放的有效药物载体的实际应用。

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来源
《Dalton transactions: An international journal of inorganic chemistry》 |2018年第44期|共6页
作者
Lin Wenxin; Cui Yuanjing; Yang Yu; Hu Quan; Qian Guodong;
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作者单位

Zhejiang Sci Tech Univ Coll Mat &

Text Dept Mat Engn Hangzhou 310018 Zhejiang Peoples R China;

Zhejiang Univ State Key Lab Silicon Mat Cyrus Tang Ctr Sensor Mat &

Applicat Sch Mat Sci &

Engn Hangzhou 310027 Zhejiang Peoples R China;

Zhejiang Univ State Key Lab Silicon Mat Cyrus Tang Ctr Sensor Mat &

Applicat Sch Mat Sci &

Engn Hangzhou 310027 Zhejiang Peoples R China;

Hangzhou Normal Univ Sch Med Dept Pharm Hangzhou 310036 Zhejiang Peoples R China;

Zhejiang Univ State Key Lab Silicon Mat Cyrus Tang Ctr Sensor Mat &

Applicat Sch Mat Sci &

Engn Hangzhou 310027 Zhejiang Peoples R China;

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正文语种 eng
中图分类化学;无机化学;
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1. A biocompatible metal-organic framework as a pH and temperature dual-responsive drug carrier [J] . Lin Wenxin, Cui Yuanjing, Yang Yu, Dalton transactions: An international journal of inorganic chemistry . 2018,第44期

机译：一种生物相容性金属有机框架作为pH和温度双响应药物载体
2. Biocompatible PEG-Chitosan@Carbon Dots Hybrid Nanogels for Two-Photon Fluorescence Imaging, Near-Infrared Light/pH Dual-Responsive Drug Carrier, and Synergistic Therapy [J] . Wang Hui, Di Jing, Sun Yubing, Advanced Functional Materials . 2015,第34期

机译：具有生物相容性的PEG-壳聚糖@碳点混合纳米凝胶，用于双光子荧光成像，近红外/ pH双反应药物载体和协同治疗。
3. Biocompatible smart cellulose nanofibres for sustained drug release via pH and temperature dual-responsive mechanism [J] . Liang Yuting, Zhu Hongxiang, Wang Lei, Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides . 2020,第1期

机译：生物相容性纤维纤维素纳米纤维，用于通过pH和温度双响应机构进行持续的药物释放
4. Biocompatible Poly(N-vinyl-2-caprolactam) derivative with pH-dependent Lower Critical Solution Temperature (LCST) Behaviors for Smart Drug delivery [C] . Yu Cao, Thomas D. Gilmartin, Shuangcheng Tang, World biomaterials congress . 2012

机译：具有pH依赖性下临界溶液温度（LCST）行为的生物相容性聚（N-乙烯基-2-己内酰胺）衍生物，可实现智能药物输送
5. A systematic study of the influence of non-covalent interactions, pH, and temperature on the synthesis and structures of metal-organic frameworks. [D] . Go, Yong Bok. 2006

机译：系统研究非共价相互作用，pH和温度对金属-有机骨架的合成和结构的影响。
6. Biocompatible Fe-Based Micropore Metal-Organic Frameworks as Sustained-Release Anticancer Drug Carriers [O] . Xin Leng, Xiaoxv Dong, Wenping Wang, 2018

机译：生物相容性铁基微孔金属有机骨架作为缓释抗癌药物载体
7. Biocompatible PEG-Chitosan@Carbon Dots Hybrid Nanogels for Two-Photon Fluorescence Imaging, Near-Infrared Light/pH Dual-Responsive Drug Carrier, and Synergistic Therapy [O] . Hui Wang, Jing Di, Yubing Sun, 2015

机译：生物相容性PEG-壳聚糖@二光子荧光成像的碳点杂交纳米凝胶，近红外光/ pH双响应药物载体，以及协同疗法

A biocompatible metal-organic framework as a pH and temperature dual-responsive drug carrier

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