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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Mesoporous silica nanoparticles incorporating squaraine-based photosensitizers: a combined experimental and computational approach
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Mesoporous silica nanoparticles incorporating squaraine-based photosensitizers: a combined experimental and computational approach

机译：含有Squaraine的光敏剂的中孔二氧化硅纳米粒子：一种组合的实验和计算方法

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摘要

Squaraine dyes, that exhibit intense absorption in the red/near infrared region, have been successfully introduced into mesoporous silica nanoparticles (MSNs) to obtain a nanoplatform for photodynamic therapy. Three brominated squaraine dyes which exhibited good PS performance in solution but a different behaviour in vitro due to cell permeability issues were used as photosensitizers. The effects of the adsorption within the pores of MSNs on the overall UV-Vis-NIR absorption and emission properties as well as on the PS performance was evaluated via a combined experimental and computational physicochemical approach, which allowed us to correlate the unusual optical properties of two out of three systems with the dimerization of squaraines on the silica surface, with detrimental effects on the PS performance. Conversely, the nanoplatform where the squaraine molecules are adsorbed as monomers on the silica surface exhibited the best activity in singlet oxygen generation.
机译：在红色/近红外区域中表现出强烈吸收的Squaraine染料已经成功地引入了介孔的二氧化硅纳米颗粒（MSN）中以获得光动力治疗的纳米载作用。 在溶液中表现出良好PS性能的三种溴化鳞状染料，但由于细胞渗透性问题的体外不同的行为被用作光敏剂。 通过组合的实验和计算物理化学方法评估MSN孔内的吸附在MSN的孔内以及PS性能上的影响，使我们允许我们关联不寻常的光学性质 三种系统中的两个系统，二氧化硅表面上的鳞片化二聚体，对PS性能有害影响。 相反，当二氧化硅表面上的单体被吸附的纳米替纳米分子被吸附的纳米片形成，在单次氧气产生中表现出最佳活性。

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    Miletto Ivana; Fraccarollo Alberto; Barbero Nadia; Barolo Claudia; Cossi Maurizio; Marchese Leonardo; Gianotti Enrica;

  • 作者单位

    Univ Piemonte Orientale Amedeo Avogadro Dipartimento Sci &

    Innovaz Tecnol Viale Teresa Michel 11 I-15100 Alessandria Italy;

    Univ Piemonte Orientale Amedeo Avogadro Dipartimento Sci &

    Innovaz Tecnol Viale Teresa Michel 11 I-15100 Alessandria Italy;

    Univ Torino Dipartimento Chim Via Pietro Giuria 7 I-10125 Turin Italy;

    Univ Torino Dipartimento Chim Via Pietro Giuria 7 I-10125 Turin Italy;

    Univ Piemonte Orientale Amedeo Avogadro Dipartimento Sci &

    Innovaz Tecnol Viale Teresa Michel 11 I-15100 Alessandria Italy;

    Univ Piemonte Orientale Amedeo Avogadro Dipartimento Sci &

    Innovaz Tecnol Viale Teresa Michel 11 I-15100 Alessandria Italy;

    Univ Piemonte Orientale Amedeo Avogadro Dipartimento Sci &

    Innovaz Tecnol Viale Teresa Michel 11 I-15100 Alessandria Italy;

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  • 正文语种 eng
  • 中图分类 化学;无机化学;
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