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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Redox-responsive UCNPs-DPA conjugated NGO-PEG-BPEI-DOX for imaging-guided PTT and chemotherapy for cancer treatment
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Redox-responsive UCNPs-DPA conjugated NGO-PEG-BPEI-DOX for imaging-guided PTT and chemotherapy for cancer treatment

机译：氧化还原响应性UCNPS-DPA共轭NGO-PEG-BPEI-DOX用于成像引导的PTT和癌症治疗化疗

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摘要

The disulfide bond (-S-S-) is an enormously valuable functional group in a variety of chemical and biological agents that display effective reactivity or biological activities (e.g., antitumor activities). The disulfide bonds prevalent in proteins are somewhat oxidizing in the extracellular space; however, such disulfide bonds can rarely be found inside cells because of disulfide cleavage reactions facilitated by abundant free cellular thiols, including glutathione (GSH), which is the most important common thiol-containing small molecule. Interestingly, intracellular GSH concentrations are considerably higher in cancer cells than in analogous normal cells; this feature may prove to be significant in the development of anticancer drug delivery systems (DDS). Moreover, upconversion nanoparticles (UCNPs) have been extensively investigated in multimodal imaging, photodynamic therapy (PDT) and photothermal therapy. UCNPs exploit near-infrared excitation instead of ultraviolet excitation and possess exclusive properties, which include greatly increased penetration depth in biological samples and reductions in background autofluorescence, photobleaching and photodamage to biological specimens. These fascinating optical features of UCNPs may broaden their prospects in the fields of imaging and therapy. Graphene has emerged as a flat monolayer of carbon atoms that are tightly embedded in a two-dimensional (2D) honeycomb lattice. Widespread research has been carried out on graphene in recent years owing to its exclusive shape and size, as well as innumerable fascinating physical and chemical properties. Owing to their high optical absorption in the near-infrared (NIR) region, graphene and GO have been extensively employed for photothermal therapy (PTT). In this study, we attempted to merge the properties of these compounds by conjugating UCNPs and NGO-PEG-BPEI-DOX into a single platform for chemotherapy and photothermal therapy.
机译：二硫键（-S-S-）是一种在各种化学和生物制剂中具有极大有价值的官能团，其显示有效的反应性或生物活性（例如，抗肿瘤活性）。蛋白质中普遍普遍的二硫键在细胞外空间中有些氧化;然而，由于通过丰富的游离细胞硫醇（包括谷胱甘肽（GSH）包括谷胱甘肽（GSH），因此可以在细胞内很少发现这种二硫键在细胞内部可以在细胞内部发现，这是最重要的含硫醇的小分子。有趣的是，癌细胞细胞内GSH浓度比类似于类似的正常细胞相当高;在抗癌药物递送系统（DDS）的发展中，该特征可能是重要的。此外，在多模式成像，光动力疗法（PDT）和光热疗中已广泛研究上转化纳米颗粒（UCNP）。 UCNPS利用近红外激发而不是紫外线激发，具有独特的性质，包括在生物样品中的渗透深度增加，并在背景自发荧光中减少到生物标本中的背景自发荧光，光漂白和光电图。这些迷人的UCNP光学功能可能会扩大成像和治疗领域的前景。石墨烯已作为碳原子的平整体层，其紧紧地嵌入二维（2D）蜂窝晶格中。由于其独有的形状和尺寸以及无数的迷人的物理和化学性质，近年来，在石墨烯上进行了广泛的研究。由于它们在近红外（NIR）区域中的高光学吸收，石墨烯和去的是光热疗（PTT）的广泛使用。在这项研究中，我们试图通过将UCNP和NGO-PEG-BPEI-DOX缀合到单一的化疗和光热疗法平台中来合并这些化合物的性质。

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  • 作者

    Gulzar Arif; Xu Jiating; Xu Liangge; Yang Piaoping; He Fei; Yang Dan; An Guanghui; Ansari Mohd Bismillah;

  • 作者单位

    Harbin Engn Univ Key Lab Superlight Mat &

    Surface Technol Minist Educ Coll Mat Sci &

    Chem Engn Harbin 150001 Heilongjiang Peoples R China;

    Harbin Engn Univ Key Lab Superlight Mat &

    Surface Technol Minist Educ Coll Mat Sci &

    Chem Engn Harbin 150001 Heilongjiang Peoples R China;

    Harbin Engn Univ Key Lab Superlight Mat &

    Surface Technol Minist Educ Coll Mat Sci &

    Chem Engn Harbin 150001 Heilongjiang Peoples R China;

    Harbin Engn Univ Key Lab Superlight Mat &

    Surface Technol Minist Educ Coll Mat Sci &

    Chem Engn Harbin 150001 Heilongjiang Peoples R China;

    Harbin Engn Univ Key Lab Superlight Mat &

    Surface Technol Minist Educ Coll Mat Sci &

    Chem Engn Harbin 150001 Heilongjiang Peoples R China;

    Harbin Engn Univ Key Lab Superlight Mat &

    Surface Technol Minist Educ Coll Mat Sci &

    Chem Engn Harbin 150001 Heilongjiang Peoples R China;

    Harbin Engn Univ Key Lab Superlight Mat &

    Surface Technol Minist Educ Coll Mat Sci &

    Chem Engn Harbin 150001 Heilongjiang Peoples R China;

    Saudi Basic Ind Corp SABIC SABIC Technol &

    Innovat Ctr Riyadh 11551 Saudi Arabia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;无机化学;
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