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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Microfluidic Ga-68-labeling: a proof of principle study
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Microfluidic Ga-68-labeling: a proof of principle study

机译：Microfluidic GA-68标签：原则研究证明

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摘要

Positron emission tomography (PET) as a tool for molecular imaging of cancer has gained huge interest in the last few years. Gallium-68 is a popular PET nuclide due to its favorable characteristics, like advantageous half-life (68 min) and independency of a cyclotron on-site for its production. Accordingly, several Ga-68-complexes for cancer imaging via PET have been made available during the last few years. In this work, Ga-68-labeled compounds were synthesized applying a commercially available microfluidic device for the first time. Therefore, a proof of principle study using three important radiotracers, [Ga-68] Ga-PSMA-11, [Ga-68] Ga-NODAGA-RGDyk and [Ga-68] Ga-DOTA-NOC, was designed. For all three radioligands, various synthesis parameters were evaluated and the feasibility of using a continuous flow reactor was assessed. All of the precursors were successfully radiolabeled with a radiochemical yield higher than 80%, proving the principle that a microfluidic set-up is a suitable approach for the production of Ga-68-labeled tracers.
机译：正电子发射断层扫描（PET）作为癌症分子成像的工具，在过去几年中获得了巨大的兴趣。镓-68是一种受欢迎的宠物核素，因为它具有有利的特性，如有利的半衰期（68分钟）和环绕的独立性，因为它的生产。因此，在过去几年中已经提供了通过PET进行癌症成像的几个GA-68复合物。在这项工作中，合成Ga-68标记的化合物首次施加市售的微流体装置。因此，设计了使用三个重要的放射反馈酯的原理研究证明[GA-68] GA-PSMA-11，[GA-68] GA-NODAGA-RGDYK和[GA-68] GA-DOTA-NOC。对于所有三种放射性配体，评估各种合成参数，评估使用连续流动反应器的可行性。所有前体都以高于80％的放射化学产率成功放射性标记，证明了微流体设置是生产GA-68标记示踪剂的合适方法的原理。

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