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首页> 外文期刊>Current treatment options in gastroenterology >Duodenogastric Reflux-induced (Alkaline) Esophagitis.
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Duodenogastric Reflux-induced (Alkaline) Esophagitis.

机译：十二指肠胃反流性（碱性）食管炎。

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摘要

Duodenogastric reflux is the retrograde flow of duodenal contents into the stomach that then mix with acid and pepsin. These agents can reflux into the esophagus (ie, duodenogastroesophageal reflux ) and cause gastroesophageal reflux disease (GERD) and its complications, including stricture, Barrett's esophagus, and adenocarcinoma of the esophagus. Medical and surgical treatments of DGER can be difficult. Best medical treatment is proton-pump inhibitors, which decrease DGER by inhibiting both gastric acidity and volume, making less gastric contents available to reflux into the esophagus. The addition of the gamma-aminobutyric (GABA(B)) receptor agonist baclofen may further reduce DGER in patients not responding to proton-pump inhibitors. Bile acid-binding agents (aluminum-containing antacids, cholestyramine, sucralfate, urosodeoxycholic acid) have physiologic rationale, but their efficacy is unproven. Prokinetic agents can reduce DGER and its upper gastrointestinal symptoms by promoting increased gastric emptying. In patients with medically refractory symptoms, a Roux-en-Y diversion or duodenal switch operation may be helpful.
机译：十二指肠胃反流是十二指肠内容物逆行流入胃内，然后与酸和胃蛋白酶混合。这些药物可回流到食道（即十二指肠胃食管反流）并引起胃食管反流疾病（GERD）及其并发症，包括狭窄，巴雷特食管和食道腺癌。 DGER的医学和外科治疗可能很困难。最好的药物治疗是质子泵抑制剂，它可以通过抑制胃酸和胃酸来降低DGER，从而减少胃中可回流至食道的内容物。 γ-氨基丁酸（GABA（B））受体激动剂巴氯芬的加入可能进一步降低对质子泵抑制剂无反应的患者的DGER。胆汁酸结合剂（含铝的抗酸剂，消胆胺，硫糖铝，脲去氧胆酸）具有生理学原理，但其功效尚未得到证实。促动力药可以通过促进胃排空的增加来减轻DGER及其上消化道症状。对于有难治性症状的患者，Roux-en-Y转移或十二指肠开关手术可能会有所帮助。

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