A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

Lu C.; Laws K.; Eskandari A.; Suntharalingam K.

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A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

机译：反应性氧物种产生，环加氧基酶-2抑制，癌症干细胞 - 效率四核铜（II）簇

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Tetranuclear copper(II) complexes containing multiple diclofenac and Schiff base moieties, 1-4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevating the intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.

机译：含有多个双氯芬酸和席夫碱部分1-4的四核铜（II）配合物被显示为杀死批量癌细胞和癌症干细胞（CSC），具有低微摩尔效力。最有效的复合物，1，通过升高细胞内反应性氧物质（ROS）水平并抑制环氧化酶-2（COX-2）表达来引发其细胞毒性效果。

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《Dalton transactions: An international journal of inorganic chemistry》 |2017年第38期|共5页
作者
Lu C.; Laws K.; Eskandari A.; Suntharalingam K.;
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Kings Coll London Dept Chem London SE1 1DB England;

Kings Coll London Dept Chem London SE1 1DB England;

Kings Coll London Dept Chem London SE1 1DB England;

Kings Coll London Dept Chem London SE1 1DB England;

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正文语种 eng
中图分类化学;无机化学;
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1. A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster [J] . Lu C., Laws K., Eskandari A., Dalton transactions: An international journal of inorganic chemistry . 2017,第38期

机译：反应性氧物种产生，环加氧基酶-2抑制，癌症干细胞 - 效率四核铜（II）簇
2. Biophysical analysis of cancer stem cell-potent copper(II) coordination complexes [J] . Zheng Puyi, Eskandari Arvin, Lu Chunxin, Dalton transactions: An international journal of inorganic chemistry . 2019,第18期

机译：癌症干细胞效率铜（II）协调复合物的生物物理分析
3. SYNTHESIS, CHARACTERIZATION, AND SINGLE-CRYSTAL EPR STUDIES OF THREE DINUCLEAR COPPER(II) COMPLEXES AND ONE MIXED-VALENCE TETRANUCLEAR COPPER(I)-COPPER(II) CLUSTER WITH AN ASYMMETRIC IMIDAZOLE-CONTAINING TRIPODAL LIGAND WITH COPPER(II)-COPPER(II) DIS [J] . Koolhaas GJAA., Reedijk J., Vanderplas JL., Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 1996,第6期

机译：含不对称咪唑的含三键铜配位配铜配体的三核铜（II）配合物和一价四价铜（I）-铜（II）簇的合成，表征和单晶EPR研究II）DIS
4. Spin Crossover in Cyanide-Bridged {Fe~(III)_2Fe~(II)_2} Tetranuclear Cluster with Chiral Ligand [C] . Junqiu Li, Kanegawa Shinji, Osamu Sato 日本化学会春季年会講演予稿集 . 2018

机译：氰化物桥接{Fe〜（III）_2FE〜（II）_2}与手性配体的四核簇旋转交叉
5. Dioxygen reactivity of synthetic analogues for the active site of heme-copper oxidases: Copper-ligand influences in iron(II)/copper(I)/oxygen chemistry. [D] . Kim, Eunsuk. 2005

机译：合成类似物对血红素-铜氧化酶活性部位的双氧反应性：铜-配体对铁（II）/铜（I）/氧化学的影响。
6. A reactive oxygen species-generating cancer stem cell-potent manganese(ii) complex and its encapsulation into polymeric nanoparticles [O] . Arvin Eskandari, Kogularamanan Suntharalingam 2019

机译：产生活性氧的癌症干细胞-强锰（ii）配合物及其封装到聚合物纳米颗粒中
7. A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster [O] . C. Lu, K. Laws, A. Eskandari, 2017

机译：反应性氧物种产生，环加氧基酶-2抑制，癌症干细胞 - 效率四核铜（II）簇

A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

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