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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Highly active group 11 metal complexes with alpha-hydrazidophosphonate ligands
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Highly active group 11 metal complexes with alpha-hydrazidophosphonate ligands

机译：高活性组11金属配合物与α-酰肼膦酸盐配体

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摘要

alpha-Hydrazidophosphonates are interesting scaffolds that could combine the biological properties of hydrazones and phosphonyl species, and their coordination properties remain unknown. The coordination chemistry of these ligands towards group 11 metals has been studied. A series of novel gold(I), silver(I) and copper(I) complexes with alpha-hydrazidophosphonate ligands have been prepared and characterised. The coordination geometries obtained vary from linear to trigonal planar for gold(I) to distorted trigonal planar or tetrahedral for silver(I) and copper(I). Structural characterisation of two silver derivatives shows the ligands in an O<^>N<^>O tridentate fashion, with dissimilar bond lengths. These compounds were screened for the in vitro cytotoxic activity against two tumour human cell lines such as HeLa (cervical carcinoma) and A549 (lung carcinoma). The IC50 values reveal an excellent cytotoxic activity of the metal complexes compared with the a-hydrazidophosphonate ligands alone and cisplatin.
机译：α-酰肼膦酸盐是有趣的支架，其可以结合含有腙和膦基物种的生物学性质，并且它们的配位性能仍然未知。研究了这些配体的配位化学朝向11组金属。已经制备了一系列新的金（I），银（I）和铜（I）配合物，其具有α-酰肼膦酸盐配体，并表征。获得的协调几何形状从线性到Trigonal平面的用于金（I）的Trigonal Paralar，以扭曲三角形平面或用于银（I）和铜（I）的四面向前列。两种银衍生物的结构表征显示了o <^> n <^ ^ o o三齿时的配体，具有不同的粘合长度。将这些化合物筛选用于对两种肿瘤人细胞系（如HeLa（宫颈癌）和A549（肺癌）的体外细胞毒性活性。与单独的A-酰肼膦酸盐配体和顺铂相比，IC 50值揭示了金属配合物的优异细胞毒活性。

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