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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Gold nanoparticles stabilized by cationic carbosilane dendrons: synthesis and biological properties
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Gold nanoparticles stabilized by cationic carbosilane dendrons: synthesis and biological properties

机译：通过阳离子碳硅烷树枝状稳定的金纳米粒子：合成和生物学性质

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摘要

Gold nanoparticles (AuNPs) and polycationic macromolecules are used as gene carriers. Their behaviour is dependent on several factors, such as the size and type of the framework, charge, etc. We have combined both types of systems and prepared AuNPs covered with cationic carbosilane dendrons with the aim to evaluate their biocompatibility. Water soluble dendronized cationic AuNPs were prepared following a straightforward procedure from dendrons, a gold precursor and a reducing agent in water and were characterized by H-1 NMR, transmission electron microscopy (TEM), dynamic light scattering (DLS), thermogravimetric analysis (TGA), ultraviolet spectroscopy (UV), and zeta potential (ZP). The biological properties of dendrons and AuNPs were determined by hemolysis, platelet aggregation and lymphocyte proliferation. These assays reflect modification of dendron properties when covering nanoparticles. For dendrons, hemolysis and platelet aggregation are generation dependent whilst, for AuNPs these properties are related to the bigger size of NPs. On the other hand, none of the systems induced lymphocyte proliferation. Selected cationic dendrons and AuNPs were chosen for gene delivery experiments employing a small interference RNA (siRNA Nef) against human immunodeficiency virus (HIV).
机译：金纳米颗粒（AUNP）和聚阳离子大分子用作基因载体。他们的行为取决于诸如框架，充电等的大小和类型，如框架，电荷等。我们组合了两种类型的系统，并准备好覆盖着阳离子碳硅烷树枝状的AuNP，目的是评估它们的生物相容性。通过在水中的直接的程序，水中的直接程序，在水中的直接程序中制备水溶性的树枝状阳离子阳离子，并通过H-1 NMR，透射电子显微镜（TEM），动态光散射（DLS），热重分析（TGA ），紫外光谱（UV）和Zeta电位（ZP）。通过溶血，血小板聚集和淋巴细胞增殖测定树枝状细胞和剖腹产的生物学性质。这些测定反映在覆盖纳米颗粒时的树突性质的改变。对于树枝状，溶血和血小板聚集在依赖于依赖，对于AUNPS，这些属性与NPS的更大尺寸有关。另一方面，没有系统诱导淋巴细胞增殖。选择选定的阳离子树枝和AuNP，用于采用针对人免疫缺陷病毒（HIV）的小干扰RNA（siRNA Nef）的基因递送实验。

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