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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Recent development of luminescent rhenium(I) tricarbonyl polypyridine complexes as cellular imaging reagents, anticancer drugs, and antibacterial agents
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Recent development of luminescent rhenium(I) tricarbonyl polypyridine complexes as cellular imaging reagents, anticancer drugs, and antibacterial agents

机译：发光铼（I）三羰基萘吡啶复合物作为细胞成像试剂，抗癌药物和抗菌剂的最新发展

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摘要

There has been fast-growing interest in the exploitation of the photophysical and photochemical properties of luminescent transition metal complexes in biological applications, with a focus on both diagnostic and therapeutic aspects. In particular, the design of luminescent rhenium(I) tricarbonyl polypyridine complexes as cellular imaging reagents and anticancer drugs has received considerable attention for a number of reasons. First, most rhenium(I) tricarbonyl polypyridine complexes possess diverse photophysical and photochemical properties through the coordination of functionalized ligands. The typical photophysical properties of the complexes such as large Stokes shifts, long emission lifetimes, and high photostability allow them to serve as attractive candidates for optical imaging. Also, the cellular uptake of the complexes can be readily quantified by atomic absorption spectroscopy and inductively coupled plasma-mass spectrometry. Additionally, owing to the characteristic infrared absorption bands and the isostructural relationship between rhenium and technetium-99m, rhenium(I) tricarbonyl complexes have been exploited as multimodal imaging reagents for vibrational and radio-imaging, respectively. Furthermore, the facile photosensitizing properties and the three carbon monoxide (CO) ligands render rhenium(I) tricarbonyl complexes promising candidates as photodynamic therapy reagents and photoactivatable CO-releasing molecules, respectively, for cancer treatment. In this Perspective, we describe the recent development of luminescent rhenium(I) tricarbonyl polypyridine complexes as cellular imaging reagents, anticancer drugs, and antibacterial agents.
机译：对生物应用中发光过渡金属配合物的光物理和光化学特性进行了快速增长的兴趣，重点关注诊断和治疗方面。特别地，由于多种原因，发光铼（I）三羰基萘吡啶络合物作为细胞成像试剂和抗癌药物的设计得到了相当大的关注。首先，大多数铼（I）三羰基萘吡啶络合物通过官能化配体的配位具有不同的光学性和光化学性质。诸如大型斯托克斯偏移，长发射寿命和高光稳定性的复合物的典型光物理性质允许它们用作光学成像的吸引力。而且，通过原子吸收光谱和电感耦合等离子体质谱法容易地定量络合物的细胞吸收。另外，由于铼和铼 - 99M之间的特征红外吸收带和异部件关系，铼（I）三羰基复合物分别被利用为用于振动和无线电成像的多模式成像试剂。此外，容易光敏性质和三种一氧化碳（CO）配体呈现铼（I）三羰基复合物，其分别具有光动力治疗试剂和可光活化的共释放分子，用于癌症治疗。在这种观点中，我们描述了最近发光铼（I）三羰基萘葡萄蛋白复合物作为细胞成像试剂，抗癌药物和抗菌剂的发展。

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