...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Development >RDH10-mediated retinol metabolism and RAR alpha-mediated retinoic acid signaling are required for submandibular salivary gland initiation (vol 145, dev164822, 2018)
【24h】

RDH10-mediated retinol metabolism and RAR alpha-mediated retinoic acid signaling are required for submandibular salivary gland initiation (vol 145, dev164822, 2018)

机译：RDH10介导的视黄醇代谢和RARα介导的视黄酸信号是潜水腺唾液腺启动所必需的（Vol 145，Dev164822,2018）

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In mammals, the epithelial tissues of major salivary glands generate saliva and drain it into the oral cavity. For submandibular salivary glands (SMGs), the epithelial tissues arise during embryogenesis from naive oral ectoderm adjacent to the base of the tongue, which begins to thicken, express SOX9 and invaginate into underlying mesenchyme. The developmental mechanisms initiating salivary gland development remain unexplored. In this study, we show that retinoic acid (RA) signaling activity at the site of gland initiation is colocalized with expression of retinol metabolic genes Rdh10 and Aldh1a2 in the underlying SMG mesenchyme. Utilizing a novel ex vivo assay for SMG initiation developed for this study, we show that RDH10 and RA are required for salivary gland initiation. Moreover, we show that the requirement for RA in gland initiation involves canonical signaling through retinoic acid receptors (RAR). Finally, we show that RA signaling essential for gland initiation is transduced specifically through RAR alpha, with no contribution from other RAR isoforms. This is the first study to identify a molecular signal regulating mammalian salivary gland initiation.
机译：在哺乳动物中，主要唾液腺的上皮组织产生唾液并将其排放到口腔中。对于颌下唾液腺（SMG），上皮组织在邻近舌碱基的胚胎发生期间出现的上皮组织，其开始增厚，表达SOX9并将其侵入下层间充质。发起唾液腺开发的发展机制仍未开发。在该研究中，我们表明，在底层SMG间充质中的视黄醇代谢基因RDH10和ALDH1A2的表达，在腺体开始的视黄酸（RA）信号传导活性在下面的SMG间能中的表达。利用新的exvivo测定用于为该研究开发的SMG发育，我们表明唾液腺引发需要RDH10和RA。此外，我们表明对腺体中Ra的要求涉及通过视黄酸受体（RAR）的规范信号传导。最后，我们表明通过RARα特异性地通过RARα转导对抗腺引起的RA信号传导，而其他RAR同种型没有贡献。这是第一次确定调节哺乳动物唾液腺引发的分子信号的研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号