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首页> 外文期刊>Development >Sidestep-induced neuromuscular miswiring causes severe locomotion defects in Drosophila larvae
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Sidestep-induced neuromuscular miswiring causes severe locomotion defects in Drosophila larvae

机译：罕见的神经肌肉误导导致果蝇幼虫的严重运动缺陷

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摘要

Mutations in motor axon guidance molecules cause aberrant projection patterns of motor nerves. As most studies in Drosophila have analysed these molecules in fixed embryos, the consequences for larval locomotion are entirely unexplored. Here, we took advantage of sidestep (side)-mutant larvae that display severe locomotion defects because of irreparable innervation errors. Mutations in side affected all motor nerve branches and all body wall regions. Innervation defects were non-stereotypical, showing unique innervation patterns in each hemisegment. Premature activation of Side in muscle precursors abrogated dorsal migration of motor nerves, resulting in larvae with a complete loss of neuromuscular junctions on dorsal-most muscles. High-speed videography showed that these larvae failed to maintain substrate contact and inappropriately raised both head and tail segments above the substrate, resulting in unique 'arching' and 'lifting' phenotypes. These results show that guidance errors in side mutants are maintained throughout larval life and are asymmetrical with respect to the bilateral body axis. Together with similar findings in mice, this study also suggests that miswiring could be an underlying cause of inherited movement disorders.
机译：电动机轴突引导分子中的突变导致电机神经的异常投影模式。由于大多数在果蝇的研究已经分析了固定胚胎中的这些分子，因此对幼虫运动的后果完全是未开发的。在这里，我们利用了索引（侧） - 级别幼虫，由于不可挽回的支配误差，显示出严重的运动缺陷。侧面的突变影响了所有运动神经分支和所有身体墙面区域。支配缺陷是非陈规定型的，在每个血液中显示出独特的支撑图案。肌肉前体的过早激活肌肉前体缺失的电动神经背部迁移，导致幼虫，具有完全丧失的神经肌肉连接物，对背部肌肉进行完全损失。高速摄像摄影摄影显示，这些幼虫未能保持基板接触并不恰当地升高在基材上方的头部和尾段，导致独特的“拱形”和“提升”表型。这些结果表明，侧突变体中的引导误差在整个幼虫寿命中保持，并且相对于双侧体轴不对称。本研究还表明，遗传失误可能是遗传运动障碍的潜在原因。

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