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首页> 外文期刊>Development >Downregulation of homeodomain protein Cut is essential for Drosophila follicle maturation and ovulation
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Downregulation of homeodomain protein Cut is essential for Drosophila follicle maturation and ovulation

机译：同源域蛋白切割的下调对于果蝇卵泡成熟和排卵是必不可少的

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摘要

Proper development and maturation of a follicle is essential for successful ovulation and reproduction; however, the molecular mechanisms for follicle maturation, particularly for somatic follicle cell differentiation, are poorly understood. During Drosophila oogenesis, the somatic follicle cells encasing oocytes undergo two distinct well-established transitions: the mitotic to endocycle switch at stage 6/7 and the endocycle to gene amplification switch at stage10A/10B. Here, we identify a novel third follicle cell transition that occurs in the final stages of oogenesis (stage 13/14). This late follicle cell transition is characterized by upregulation of the transcription factor Hindsight (Hnt), and downregulation of the homeodomain transcription factor Cut and the zinc-finger transcription factor Tramtrack-69 (Ttk69). We demonstrate that inducing expression of Cut in stage 14 follicle cells is sufficient to inhibit follicle rupture and ovulation through its negative regulation of Hnt and promotion of Ttk69 expression. Our work illustrates the importance of the stage13/14 transition for follicle maturation and demonstrates the complex regulation required for somatic follicle cells to differentiate into a state primed for follicle rupture and ovulation.
机译：毛囊的适当发展和成熟对于成功的排卵和繁殖是必不可少的;然而，卵泡成熟的分子机制，特别是对于体细胞毛囊细胞分化较差。在果蝇Oferocis期间，包裹卵母细胞的体细胞卵泡细胞经历两种明显的良好的过渡：在第6/7阶段的阶段，内圆周切换有丝分裂和在第10A / 10b处的基因扩增开关。在这里，我们鉴定了在OFORYES内的最终阶段发生的新型第三卵泡细胞转变（第13/14阶段）。这种晚期卵泡细胞转变的特征在于转录因子后敏感（HNT），以及双常域转录因子切割和锌指转录因子轨道Track-69（TTK69）的下调。我们证明诱导阶段14卵泡细胞中切割的表达足以通过其HNT的负调节和TTK69表达的负调节来抑制卵泡破裂和排卵。我们的作品说明了卵泡成熟的第14类/ 14转变的重要性，并证明了体细胞卵泡细胞所需的复杂调节，以分化为毛囊破裂和排卵的状态。

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