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首页> 外文期刊>Diabetes care >Comparing Type 2 Diabetes, Prediabetes, and Their Associated Risk Factors in Asian Indians in India and in the US: The CARRS and MASALA Studies
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Comparing Type 2 Diabetes, Prediabetes, and Their Associated Risk Factors in Asian Indians in India and in the US: The CARRS and MASALA Studies

机译：在印度和美国的亚洲印第安人中比较2型糖尿病，Prediabetes及其相关的危险因素：Carrs和Masala研究

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OBJECTIVETo assess the prevalence of diabetes and prediabetes and the associated risk factors in two Asian Indian populations living in different environments.RESEARCH DESIGN AND METHODSWe performed cross-sectional analyses, using representative samples of 2,305 Asian Indians aged 40-84 years living in Chennai, India, from the Centre for cArdiometabolic Risk Reduction in South-Asia study (CARRS) (2010-2011), and 757 Asian Indians aged 40-84 years living in the greater San Francisco and Chicago areas from the U.S. Mediators of Atherosclerosis in South Asians Living in America (MASALA) study (2010-2013). Diabetes was defined as self-reported use of glucose-lowering medication, fasting glucose 126 mg/dL, or 2-h glucose 200 mg/dL. Prediabetes was defined as fasting glucose 100-125 mg/dL and/or 2-h glucose 140-199 mg/dL.RESULTSAge-adjusted diabetes prevalence was higher in India (38% [95% CI 36-40]) than in the U.S. (24% [95% CI 21-27]). Age-adjusted prediabetes prevalence was lower in India (24% [95% CI 22-26]) than in the U.S. (33% [95% CI 30-36]). After adjustment for age, sex, waist circumference, and systolic blood pressure, living in the U.S. was associated with an increased odds for prediabetes (odds ratio 1.2 [95% CI 0.9-1.5]) and a decreased odds for diabetes (odds ratio 0.5 [95% CI 0.4-0.6]).CONCLUSIONSThese findings indicate possible changes in the relationship between migration and diabetes risk and highlight the growing burden of disease in urban India. Additionally, these results call for longitudinal studies to better identify the gene-environment-lifestyle exposures that underlie the elevated risk for type 2 diabetes development in Asian Indians.
机译：ObjectiveTo评估糖尿病和前脂肪脂肪的患病率，以及生活在不同环境中的两个亚洲印度人口中的相关危险因素。搜索设计和方法进行了横断面分析，使用了4,305岁的亚洲印第安人居住在印度钦奈居住的代表样本，来自南亚南亚研究（CARS）（2010-2011）（2010-2011）（2010-2011）（居住在大旧金山和芝加哥）的757名亚洲印第安人，来自美国南亚南亚洲的动脉粥样硬化的芝加哥地区，757岁的亚洲印第安人在美国（Masala）学习（2010-2013）。糖尿病被定义为自我报告的葡萄糖降低用途，葡萄糖126mg / dl，或2-H葡萄糖200mg / dl。 PrediaBetes被定义为空腹葡萄糖100-125mg / dl和/或2-H葡萄糖140-199mg / dl.resultsage调整后的糖尿病在印度较高（38％[95％ci 36-40]）比在美国（24％[95％CI 21-27]）。在美国的年龄调整后的前脂肪率较低（24％[95％CI 22-26]），而不是美国（33％[95％CI 30-36]）。在调整年龄，性别，腰围和收缩压后，生活在美国的血压与前奶脂酸脂肪的赔率增加有关（差距1.2 [95％CI 0.9-1.5]）和糖尿病的赔率降低（差价率为0.5 [95％CI 0.4-0.6]）。结论STERHESE调查结果表明迁移和糖尿病风险之间关系的可能变化，并突出了印度城市城市疾病的不断增长。此外，这些结果要求纵向研究，以更好地识别基因 - 环境 - 生活方式暴露，使亚洲印第安人2型糖尿病发育的升高风险。

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  • 来源
    《Diabetes care》 |2015年第7期|共7页
  • 作者

    Gujral Unjali P.; Narayan K. M. Venkat; Pradeepa R. Ghua; Deepa Mohan; Ali Mohammed K.; Anjana Ranjit M.; Kandula Namratha R.; Mohan Viswanathan; Kanaya Alka M.;

  • 作者单位

    Emory Univ Nutr &

    Hlth Sci Program Grad Div Biomed &

    Biol Sci Laney Grad Sch Atlanta GA 30322;

    Emory Univ Nutr &

    Hlth Sci Program Grad Div Biomed &

    Biol Sci Laney Grad Sch Atlanta GA 30322;

    Int Diabet Federat Ctr Educ WHO Collaborating Ctr Noncommunicable Dis Prevent Madras Diabet Res;

    Int Diabet Federat Ctr Educ WHO Collaborating Ctr Noncommunicable Dis Prevent Madras Diabet Res;

    Emory Univ Nutr &

    Hlth Sci Program Grad Div Biomed &

    Biol Sci Laney Grad Sch Atlanta GA 30322;

    Int Diabet Federat Ctr Educ WHO Collaborating Ctr Noncommunicable Dis Prevent Madras Diabet Res;

    Northwestern Univ Dept Gen Internal Med Feinberg Sch Med Chicago IL 60611 USA;

    Int Diabet Federat Ctr Educ WHO Collaborating Ctr Noncommunicable Dis Prevent Madras Diabet Res;

    Univ Calif San Francisco Div Gen Internal Med San Francisco CA 94143 USA;

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  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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