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首页> 外文期刊>Diabetes care >Sex differences in the association between serum ferritin and fasting glucose in type 2 diabetes among South Asian Surinamese, African Surinamese, and ethnic Dutch: The population-based SUNSET study
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Sex differences in the association between serum ferritin and fasting glucose in type 2 diabetes among South Asian Surinamese, African Surinamese, and ethnic Dutch: The population-based SUNSET study

机译：南亚苏里南亚，非洲苏里南亚南亚苏里南亚型糖尿病患者血清铁素与空腹葡萄糖之间的性差异：基于人口的日落研究

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OBJECTIVE-Moderately elevated iron stores below the levels commonly associated with hemochromatosis have been implicated in the etiology of diabetes. Studies suggest that iron status (measured by serum ferritin) differs significantly according to sex, but inconsistent findings have been reported. Our aim is to test the association between serum ferritin and the prevalence of type 2 diabetes and fasting glucose concentrations in a population-based, multiethnic, cross-sectional study including men and women of African Surinamese, South Asian Surinamese, and ethnic Dutch origin. RESEARCH DESIGN AND METHODS-We analyzed data on 508 ethnic Dutch, 597 African Surinamese, and 339 South Asian Surinamese aged 35-60 years. Type 2 diabetes was defined as a fasting plasma glucose level ??7.0 mmol/L or a self-reported diagnosis. RESULTS-Serum ferritin was positively associated with type 2 diabetes and fasting glucose, but differences in the associations according to sex were observed. Serum ferritin concentration was positively associatedwith type 2 diabetes among women in all ethnic groups (odds ratio [OR] ethnic Dutch: 1.07 [95% CI 1.01-1.13]; OR South Asian Surinamese: 1.05 [1.00-1.10]; OR African Surinamese: 1.05 [1.01-1.10]), but not among men. Serum ferritin was also more strongly associated with fasting glucose in women than in men. Moreover, the magnitude of sex differences in the association between serum ferritin and fasting glucose, but not type 2 diabetes, was more pronounced in the African Surinamese group than in the other ethnic groups (P for interaction ??0.0001). CONCLUSIONS-We found a positive association between serum ferritin and type 2 diabetes and fasting glucose in our multiethnic population, which appeared stronger among women than men. Further evaluation of the variation in sex differences between ethnic groups is warranted, particularly among the African Surinamese, to understand the mechanisms behind these sex differences. ? 2013 by the American Diabetes Association.
机译：下面通常与血色素沉着水平目的-适度升高的铁储备有牵连的糖尿病的病因。研究表明，铁状态（通过血清铁蛋白测量）而不同显著根据性别，但不一致的结果已经报道。我们的目的是测试在一个人口为基础的，多民族，横断面研究，包括非洲苏里南，南亚苏里南和种族荷兰籍的男性和女性血清铁蛋白和2型糖尿病的患病率和空腹血糖浓度之间的关联。研究设计和方法，我们分析了508族裔荷兰，非洲597苏里南和339南亚苏里南年龄在35-60年的数据。 2型糖尿病被定义为空腹血糖水平?? 7.0毫摩尔/ L或自我报告的诊断。结果-血清铁蛋白呈正患有2型糖尿病和空腹血糖相关，但观察到在根据性别关联差异。血清铁蛋白浓度呈正associatedwith类型中的各族妇女[比值比（OR]荷兰本民族2型糖尿病：1.07 [95％CI 1.01-1.13];或南亚苏里南：1.05 [1.00-1.10];或非洲苏里南： 1.05 [1.01-1.10]），而不是男性。血清铁蛋白也更强烈空腹血糖的女性比男性有关。此外，在血清铁蛋白和空腹血糖之间的关联性差的大小，而不是2型糖尿病，更明显在非洲苏里南组比其他族群（P相互作用?? 0.0001）。结论，我们发现在我们的多种族人口的血清铁蛋白与2型糖尿病和空腹血糖之间的正相关性，这其中女性比男性更强的出现。在民族之间的性别差异的变化进一步评估是必要的，特别是在非洲苏里南，了解这些背后的性别差异的机制。还是2013年由美国糖尿病协会。

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  • 来源
    《Diabetes care》 |2013年第4期|共7页
  • 作者

    DekkerL.H.; NicolaouM.; VanDerAD.L.; BusschersW.B.; BrewsterL.M.; SnijderM.B.; StronksK.; VanValkengoedI.G.M.;

  • 作者单位

    Department of Public Health Academic Medical Center University of Amsterdam Amsterdam;

    Department of Public Health Academic Medical Center University of Amsterdam Amsterdam;

    National Institute for Public Health and the Environment Bilthoven Netherlands;

    Department of Public Health Academic Medical Center University of Amsterdam Amsterdam;

    Department of Vascular Medicine Academic Medical Center University of Amsterdam Amsterdam;

    Department of Public Health Academic Medical Center University of Amsterdam Amsterdam;

    Department of Public Health Academic Medical Center University of Amsterdam Amsterdam;

    Department of Public Health Academic Medical Center University of Amsterdam Amsterdam;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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