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Chronic idiopathic axonal polyneuropathy is associated with the metabolic syndrome

机译：慢性发作性轴突变性多病变与代谢综合征有关

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OBJECTIVE-This study aims to investigate the association between chronic idiopathic axonal polyneuropathy (CIAP) and the metabolic syndrome or its individual components. RESEARCH DESIGN AND METHODS-A total of 249 patients with CIAP and 709 controls underwent fasting laboratory studies, and blood pressure and waist circumference were measured. The metabolic syndrome was diagnosed if three or more of the following Adult Treatment Panel III criteria were present: impaired fasting glucose, hypertension, abdominal obesity, reduced HDL cholesterol, and hypertriglyceridemia. Subgroup analysis was performed for patients with a painful predominantly sensory CIAP, because this phenotype is most similar to diabetic polyneuropathy. Statistical analysis was performed with adjustment for age and gender. RESULTS-Fifty-five percent of all patients fulfilled the metabolic syndrome criteria compared with 34% of controls (odds ratio 2.2 [95% CI 1.7-3.0]). Multivariate analysis shows hypertension (2.9 [1.7-4.9]) and abdominal obesity (3.3 [2.4-4.6]) to be significantly more prevalent in patients than in controls. Of the patients classified as having a painful predominantly sensory CIAP, 62% fulfilled the metabolic syndrome criteria (3.1 [2.0-4.8]). In this subgroup, hypertension and abdominal obesity also were significantly more prevalent compared with controls. CONCLUSIONS-Abdominal obesity and hypertension seem to be the most consistent contributing components of the metabolic syndrome in patients with CIAP. Evaluation and appropriate treatment of these risk factors in patients with CIAP would be advocated. ? 2013 by the American Diabetes Association.
机译：目的 - 该研究旨在探讨慢性发作性轴突性多变病变（CIAP）与代谢综合征或其各个组分之间的关​​联。研究设计和方法 - 共249例CIAP和709患者进行了禁食实验室研究，并测量了血压和腰围。如果存在以下成人治疗组III标准的三种或更多种或更多的成人治疗组合标准，则诊断代谢综合征：空腹葡萄糖，高血压，腹部肥胖，还原的HDL胆固醇和高甘油血症症。对患有痛苦的感觉CIAP的患者进行亚组分析，因为这种表型最类似于糖尿病多种病变。通过调整年龄和性别进行统计分析。结果 - 所有患者的55％均满足代谢综合征标准，而34％的对照（差距2.2 [95％CI 1.7-3.0]）。多变量分析显示高血压（2.9 [1.7-4.9]）和腹部肥胖（3.3 [2.4-4.6]）患者显着普遍存在于对照。分类为具有疼痛的患者主要是感觉CIAP，62％满足代谢综合征标准（3.1 [2.0-4.8]）。在该亚组中，与对照组相比，高血压和腹部肥胖也显着普遍。结论 - 腹部肥胖和高血压似乎是CIAP患者代谢综合征最一致的贡献组成部分。提倡对CIAP患者的评价和适当治疗这些风险因素。还是2013年由美国糖尿病协会。

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  • 来源
    《Diabetes care》 |2013年第4期|共6页
  • 作者

    VisserN.A.; VranckenA.F.J.E.; VanDerSchouwY.T.; VanDenBergL.H.; NotermansN.C.;

  • 作者单位

    Rudolf Magnus Institute of Neuroscience Department of Neurology University Medical Center Utrecht;

    Rudolf Magnus Institute of Neuroscience Department of Neurology University Medical Center Utrecht;

    Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht;

    Rudolf Magnus Institute of Neuroscience Department of Neurology University Medical Center Utrecht;

    Rudolf Magnus Institute of Neuroscience Department of Neurology University Medical Center Utrecht;

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  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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