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首页> 外文期刊>Diabetes care >Fibroblast growth factor 21 levels in young healthy females display day and night variations and are increased in response to short-term energy deprivation through a leptin-independent pathway
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Fibroblast growth factor 21 levels in young healthy females display day and night variations and are increased in response to short-term energy deprivation through a leptin-independent pathway

机译：成纤维细胞生长因子21水平在年轻健康的女性中显示日和夜间变异，并且响应通过瘦素无关的途径而增加的短期能量剥夺

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OBJECTIVE-Fibroblast growth factor (FGF)-21 is an endocrine factor with potentmetabolic effects. Its day-night patterns of secretion and/or its physiological response to energy deprivation and relationship to free fatty acids (FFAs) and/or leptin remain to be fully elucidated.We aim to elucidate day-night pattern of FGF-21 levels and its relationship to FFA, to assesswhether energy deprivation alters its circulating patterns, and to examine whether leptin may mediate these changes. RESEARCH DESIGN AND METHODS-Six healthy lean females were studied for 72 h in a cross-over interventional study under three different conditions: on isocaloric diet and in a fasting state with administration of either placebo or metreleptin in physiological replacement doses. Blood samples were obtained hourly from 8:00 A.M. on day 4 until 8:00 A.M. on day 5. RESULTS-FGF-21 exhibited day-night variation pattern during the isocaloric fed state. Fasting significantly increased FGF-21 levels (P < 0.01) via a leptin-independent pathway. Day-night variation pattern in the fed state was lost on fasting. Leptin replacement in the hypoleptinemic state restored approximate entropy of FGF-21 time series but did not alter circulating levels. FGF-21 levels were closely cross-correlated with FFA levels in all three states. CONCLUSIONS-A day-night variation in the levels of FGF-21 exists in young lean females in the fed state. Energy deprivation increases FGF-21 levels via a leptin-independent pathway. The interaction between FGF-21 and starvation-induced lipolysis, as indicated by its close crosscorrelations with FFA in both fed state and energy deprivation, needs to be studied further. ? 2013 by the American Diabetes Association.
机译：目标 - 成纤维细胞生长因子（FGF）-21是具有稳定性代谢效应的内分泌因子。其日夜的分泌物和/或对能量剥夺和与游离脂肪酸的关系的生理反应仍然完全阐明。我们旨在阐明FGF-21水平的日夜模式及其与FFA的关系，评估能量剥夺改变其循环模式，并检查瘦素是否可以调节这些变化。研究设计和方法 - 在三种不同条件下在交叉介入研究中研究了72小时的六位健康精益女性：在异蜂鸟类和在生理替代剂量中施用安慰剂或百合素的禁食状态。每小时在上午8点开始血液样品。在第4天至下午8点到8:00。在第5天。结果-FGF-21在异蜂媒体州的异常状态下表现出日夜变化模式。通过瘦素 - 无关的途径禁食显着增加FGF-21水平（P <0.01）。美联储状态中的昼夜变异模式在禁食中丢失。瘦素替代在低渗症状态恢复FGF-21时间序列的近似熵，但没有改变循环水平。 FGF-21水平与所有三种州的FFA水平密切相关。结论 - FGF-21水平的日夜变异存在于美联储状态的年轻精益女性中。能量剥夺通过瘦蛋白无关的途径增加FGF-21水平。 FGF-21和饥饿诱导的脂肪分解之间的相互作用，如其在喂养状态和能量剥夺的FFA中与FFA的紧密跨相关性所示，需要进一步研究。还是2013年由美国糖尿病协会。

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  • 来源
    《Diabetes care》 |2013年第4期|共8页
  • 作者

    FooJ.-P.; AronisK.N.; ChamberlandJ.P.; ParuthiJ.; MoonH.-S.; MantzorosC.S.;

  • 作者单位

    Division of Endocrinology Diabetes and Metabolism Beth Israel Deaconess Medical Center Harvard;

    Division of Endocrinology Diabetes and Metabolism Beth Israel Deaconess Medical Center Harvard;

    Division of Endocrinology Diabetes and Metabolism Beth Israel Deaconess Medical Center Harvard;

    Division of Endocrinology Diabetes and Metabolism Beth Israel Deaconess Medical Center Harvard;

    Division of Endocrinology Diabetes and Metabolism Beth Israel Deaconess Medical Center Harvard;

    Division of Endocrinology Diabetes and Metabolism Beth Israel Deaconess Medical Center Harvard;

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  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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