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首页> 外文期刊>Diabetes care >Coronary calcium score predicts cardiovascular mortality in diabetes: Diabetes heart study
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Coronary calcium score predicts cardiovascular mortality in diabetes: Diabetes heart study

机译：冠状动脉钙分数预测糖尿病的心血管死亡率：糖尿病心脏研究

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OBJECTIVE-In type 2 diabetesmellitus (T2DM), it remains unclear whether coronary artery calcium (CAC) provides additional information about cardiovascular disease (CVD) mortality beyond the Framingham Risk Score (FRS) factors. RESEARCH DESIGN AND METHODS-A total of 1,123 T2DM participants, ages 34- 86 years, in the Diabetes Heart Study followed up for an average of 7.4 years were separated using baseline computed tomography scans of CAC (0-9, 10-99, 100-299, 300-999, and ??1,000). Logistic regression was performed to examine the association between CAC and CVD mortality adjusting for FRS. Areas under the curve (AUC) with and without CAC were compared. Net reclassification improvement (NRI) compared FRS (model 1) versus FRS+CAC (model 2) using 7.4-year CVD mortality risk categories 0% to <7%, 7% to <20%, and ??20%. RESULTS-Overall, 8% of participants died of cardiovascular causes during follow-up. In multivariate analysis, the odds ratios (95%CI) for CVDmortality using CAC 0-9 as the reference group were, CAC 10-99: 2.93 (0.74-19.55); CAC 100-299: 3.17 (0.70-22.22); CAC 300-999: 4.41(1.15-29.00); and CAC??1,000: 11.23 (3.24-71.00). AUC (95%CI)without CACwas 0.70 (0.67-0.73), AUC with CAC was 0.75 (0.72-0.78), and NRI was 0.13 (0.07-0.19). CONCLUSIONS-In T2DM, CAC predicts CVD mortality and meaningfully reclassifies participants, suggesting clinical utility as a risk stratification tool in a population already at increased CVD risk. ? 2013 by the American Diabetes Association.
机译：目标2型糖尿病（T2DM），仍然尚不清楚冠状动脉钙（CAC）是否提供有关框架风险评分（FRS）因素超出了关于心血管疾病（CAC）死亡率的额外信息。研究设计和方法 - 共有1,123个T2DM参与者，34-86岁，在糖尿病心脏研究中，使用基线计算机断层扫描扫描（0-9,10-99,100，平均分离平均​​7.4岁-299,300-999和?? 1,000）。进行逻辑回归以检查CAC与CAC和CVD死亡率之间的关联调整FRS。比较了曲线下的区域（AUC），没有CAC。净重新分类改善（NRI）比较FRS（型号1）与FRS + CAC（模型2）使用7.4年CVD死亡率风险类别0％至<7％，7％至<20％，以及20％。结果 - 总体而言，8％的参与者在随访期间死于心血管原因。在多变量分析中，使用CAC 0-9作为参考组CAC 10-99：2.93（0.74-19.55）的CAC 0-9的多变量比（95％CI）; CAC 100-299：3.17（0.70-22.22）; CAC 300-999：4.41（1.15-29.00）;和CAC ?? 1,000：11.23（3.24-71.00）。 AUC（95％CI）没有CACWAs 0.70（0.67-0.73），AUC含CAC为0.75（0.72-0.78），NRI为0.13（0.07-0.19）。结论 - 在T2DM中，CAC预测CVD死亡率和有意义的重新分类参与者，建议临床公用事业作为在增加CVD风险的人口中的风险分层工具。还是2013年由美国糖尿病协会。

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  • 来源
    《Diabetes care》 |2013年第4期|共6页
  • 作者

    AgarwalS.; CoxA.J.; HerringtonD.M.; JorgensenN.W.; XuJ.; FreedmanB.I.; CarrJ.J.; BowdenD.W.;

  • 作者单位

    Department of Cardiology Oakwood Hospital and Medical Center Dearborn MI United States;

    Centers for Diabetes Research and Human Genomics Wake Forest School of Medicine Winston-Salem NC;

    Department of Internal Medicine Section of Cardiology Wake Forest School of Medicine Winston;

    Department of Biostatistics University of Washington Seattle WA United States;

    Centers for Diabetes Research and Human Genomics Wake Forest School of Medicine Winston-Salem NC;

    Department of Internal Medicine Section of Nephrology Wake Forest School of Medicine Winston;

    Departments of Radiology Public Health and Translational Science Wake Forest School of Medicine;

    Centers for Diabetes Research and Human Genomics Wake Forest School of Medicine Winston-Salem NC;

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  • 中图分类 内分泌腺疾病及代谢病;
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