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Placental 11 beta-HSD2 and Cardiometabolic Health Indicators in Infancy

机译：胎盘11β-HSD2和婴儿表的心脏差价健康指标

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摘要

OBJECTIVE Fetal excessive exposure to glucocorticoids may program cardiometabolic risk. Placental 11 beta-hydroxysteroid dehydrogenase 2 (11 beta-HSD2) serves as a barrier to prevent fetal overexposure to maternal glucocorticoids. It has not been explored whether placental 11 beta-HSD2 levels are associated with cardiometabolic health in postnatal life. RESEARCH DESIGN AND METHODS In a prospective birth cohort study of 246 mother-infant pairs, we measured placental 11 beta-HSD2 expression and maternal (32-35 weeks of gestation) and cord plasma cortisol concentrations. The primary outcomes were HOMA of insulin resistance (IR) and blood pressure (BP) in infants at age 1 year. Other outcomes included fasting insulin, HOMA beta-cell function, carotid intima-media thickness, weight z score, and skinfold thickness (triceps and subscapular) at age 1 year. RESULTS Placental 11 beta-HSD2 expression was negatively correlated with HOMA-IR (r = -0.17, P = 0.021) and fasting insulin (r = -0.18, P = 0.017) and marginally negatively correlated with systolic BP (r = -0.16, P = 0.057) but was not correlated with HOMA of beta-cell function, diastolic BP, carotid intima-media thickness, and skinfold thickness (all P > 0.1) in infants at age 1 year. Cord plasma cortisol was negatively correlated to skinfold thickness (r = -0.20, P = 0007) but was not correlated with other outcomes at age 1 year. Maternal plasma cortisol was positively correlated with maximal carotid intima-media thickness (r = 0.20, P = 0.03) but was not correlated with other outcomes. Adjusting for maternal and infant characteristics, the associations were similar. CONCLUSIONS The study is the first to show that higher placental 11 beta-HSD2 expression is associated with lower IR in infancy. Independent cohort studies are required to confirm this novel finding.
机译：客观胎儿过度接触糖皮质激素可以编程心脏素质风险。胎盘11β-羟类脱氢酶2（11β-HSD2）用作防止胎儿过度含量的胎儿糖皮质激素的屏障。尚未探索胎盘11β-HSD2水平是否与后期生命中的心脏异常健康有关。在246母婴对预期出生队列研究中的研究设计与方法，我们测量胎盘11β-HSD2表达和母体（妊娠32-35周）和脐血浆皮质醇浓度。主要结果是胰岛素抵抗（IR）和血压（BP）在1年龄1年。其他结果包括禁食胰岛素，HOMAβ细胞功能，颈动脉内膜厚度，重量Z评分和1年时的肤色厚度（三头肌和蛛网）。结果胎盘11β-HSD2表达与HOMA-IR（R = -0.17，P = 0.021）呈负相关，并且禁食胰岛素（r = -0.18，p = 0.017），与收缩性bp的略微呈负相关（r = -0.16， P = 0.057）但与1年龄1年龄1年龄1年龄婴儿的β细胞功能，舒张压BP，颈动脉内膜内膜介质厚度和肤质厚度（全部P> 0.1）的蜂鸣声不相关。脐带血浆皮质醇与肤色厚度呈负相关（r = -0.20，p = 0007），但与1年龄1年龄的其他结果没有相关。母体血浆皮质醇与最大颈动脉内膜介质厚度呈正相关（r = 0.20，p = 0.03），但与其他结果没有相关。调整母婴特征，关联是相似的。结论该研究是第一个显示较高胎盘11β-HSD2表达与婴儿期下的较低IR相关。需要独立的队列研究来确认这部小说发现。

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  • 来源
    《Diabetes care》 |2019年第5期|共8页
  • 作者

    Chen Lu; Guilmette Julie; Luo Zhong-Cheng; Cloutier Anik; Wang Wen-Juan; Yang Meng-Nan; Fraser William D.; Dubois Josee; Nuyt Anne Monique;

  • 作者单位

    Mt Sinai Hosp Prosserman Ctr Populat Hlth Res Lunenfeld Tanenbaum Res Inst Dept Obstet &

    Gynecol;

    Univ Montreal St Justine Univ Hosp &

    Res Ctr Montreal PQ Canada;

    Mt Sinai Hosp Prosserman Ctr Populat Hlth Res Lunenfeld Tanenbaum Res Inst Dept Obstet &

    Gynecol;

    Univ Montreal St Justine Univ Hosp &

    Res Ctr Montreal PQ Canada;

    Mt Sinai Hosp Prosserman Ctr Populat Hlth Res Lunenfeld Tanenbaum Res Inst Dept Obstet &

    Gynecol;

    Mt Sinai Hosp Prosserman Ctr Populat Hlth Res Lunenfeld Tanenbaum Res Inst Dept Obstet &

    Gynecol;

    Univ Montreal St Justine Univ Hosp &

    Res Ctr Montreal PQ Canada;

    Univ Montreal St Justine Univ Hosp &

    Res Ctr Montreal PQ Canada;

    Univ Montreal St Justine Univ Hosp &

    Res Ctr Montreal PQ Canada;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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