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首页> 外文期刊>Current treatment options in gastroenterology >Current treatments in nonalcoholic steatohepatitis.
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Current treatments in nonalcoholic steatohepatitis.

机译：非酒精性脂肪性肝炎的当前治疗方法。

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摘要

Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in the United States secondary to the growing obesity epidemic. Although most patients with NAFLD do not develop progressive liver disease, the subset of NAFLD patients with nonalcoholic steatohepatitis (NASH) are at risk for progression to cirrhosis and hepatocellular carcinoma, which necessitates appropriate follow-up and management. Unfortunately, proven treatment modalities for NASH that result in complete histopathologic regression of steatosis, inflammation, and fibrosis do not exist. Many therapeutic approaches to NAFLD management have been attempted, with varying degrees of success. However, most of these studies have been limited to small, single-center, uncontrolled trials. Based on our evolving understanding of the disease's pathogenesis, it seems logical that a multidisciplinary approach addressing the underlying metabolic syndrome and the resultant intrinsic liver injury is necessary. Diet, exercise, surgical weight loss, diabetic medications, and hepatoprotective agents all have been studied and may serve as potential weapons in our armamentarium against this disease. Although most of these approaches have been studied as single-modality therapy, we believe that combination, multimodality therapy is required to treat this disease effectively.
机译：非酒精性脂肪肝疾病（NAFLD）已成为继肥胖症日益严重的美国最常见的慢性肝病。尽管大多数NAFLD患者未发展为进行性肝病，但部分NAFLD非酒精性脂肪性肝炎（NASH）患者有发展为肝硬化和肝细胞癌的风险，这需要适当的随访和管理。不幸的是，不存在用于导致脂肪变性，炎症和纤维化的完整组织病理学退化的经证实的NASH治疗方式。已经尝试了多种治疗NAFLD的方法，并获得了不同程度的成功。但是，这些研究大多限于小型，单中心，非对照试验。基于我们对疾病发病机理的不断发展的理解，似乎有必要采取一种多学科的方法来应对潜在的代谢综合征和由此产生的内在性肝损伤。饮食，运动，外科手术减肥，糖尿病药物和肝保护剂都已被研究过，并可能在我们对抗这种疾病的武器库中用作潜在武器。尽管这些方法中的大多数已作为单模态疗法进行了研究，但我们认为需要组合，多模态疗法才能有效治疗该疾病。

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